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All Journal Pharmaceutical And Biomedical Sciences Journal (PBSJ) Pharmacon: Jurnal Farmasi Indonesia
Reza Rahmawati
Department of Pharmacy, Faculty of Mathematics and Natural Sciences, University of Bengkulu
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

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The Effect of Administration Platycerium bifurcatum (Cav.) C.Chr  Extract on Total Bilirubin Levels and Hepatosomatic Index Values of Ethanol-Induced Rats Hendri Saputra; Reza Pertiwi; Delia Komala Sari; Septi Wulandari; Reza Rahmawati
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 7 No. 1 (2025)
Publisher : Pharmacy Department, Faculty of Health Sciences, UIN Syarif Hidayatullah Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v7i1.49112

Abstract

The Liver is a vital metabolic organ. Liver injury is related to an inflammatory process that increases the hepatosomatic index (HSI). One indicator of liver damage is increased total bilirubin levels (hyperbilirubinemia). Currently, hyperbilirubinemia treatment is still limited to irradiation therapy and exchange transfusions, because there is no pharmacological specific treatment. This study aimed to evaluate the hepatoprotective effect of Platycerium bifurcatum (Cav.) C.Chr extract on total bilirubin levels and the hepatosomatic index (HSI) in male white rats. A laboratory-based experimental design was employed using a post-test only control group, involving 35 rats randomly assigned to seven groups: normal control, negative control, positive control (sacatonic active), solvent control (Na CMC), and treatment groups receiving ethanol extract at doses of 50 mg/kgBW, 100 mg/kgBW, and 200 mg/kgBW.The treatment was administered orally for 14 consecutive days. On the final day, all rats (except the normal group) were induced with absolute ethanol at 2 mL/200 gBW. After 12 hours, the animals were euthanized for liver and blood sample collection. Total bilirubin levels were measured, and the hepatosomatic index was calculated. Data were analyzed using one-way ANOVA followed by LSD post hoc test. The results demonstrated that administration of Platycerium bifurcatum (Cav.) C.Chr extract significantly reduced total bilirubin levels and HSI, particularly at doses of 50 mg/kgBW and 100 mg/kgBW, compared to the negative control group (p<0.05). These findings suggest that Platycerium bifurcatum (Cav.) C.Chr ethanol extract exhibits a hepatoprotective effect by reducing total bilirubin levels and HIS.
Identification of Drug Related Problems (DRPs) Use of Antibiotics in Pediatric Pneumonia Patients at General Hospital Bengkulu City Halwa Balqis Mahardika; Dian Handayani; Reza Rahmawati; Sal Prima Yudha
Pharmacon: Jurnal Farmasi Indonesia Vol. 22 No. 2 (2025)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v22i2.6672

Abstract

Pneumonia in pediatrics has a high mortality rate. Primary antibiotic therapy can increase antibiotic use and cause Drug Related Problems (DRPs). This study examines the treatment profile and identifies DRPs of antibiotic use in pediatric pneumonia patients at Ummi General Hospital, Bengkulu City. This study uses a cross-sectional approach method where data is collected retrospectively through patient medical records. The population includes all pediatric patients with the main disease community-acquired-pneumonia who were treated at the Ummi General Hospital, Bengkulu City during the July-December 2022 period. The sampling technique in this study was using purposive sampling. Data was analyzed univariately, and DRPs were identified using the Pharmaceutical Care Network Europe Foundation (PCNE) algorithm version 9.1 and analyzed descriptively. The treatment profile included ampicillin inj + gentamicin inj (54.7%), sultamicillin inj (15.8%), sultamicillin inj + gentamicin inj (8.4%), ampicillin inj (8.4%), gentamicin inj (7.4%), ceftriaxone inj (3.2%), and sultamicillin inj + gentamicin inj + ceftriaxone inj (2.1%). There were 367 cases in 95 patients. Cases of DRPs included overdose (27.8%), the duration of treatment is too short (22.9%), infrequent dose regimen (18.8%), adverse drug incidence (16.9%), underdose (10.1%), drugs not following the guidelines (1.9%), the duration of treatment is too long (1.1%), and therapeutic group duplication (0.5%). The study concluded that the most common treatment was ampicillin inj + gentamicin inj (54.7), with the most frequent DRPs being overdose (27.8%), the duration of treatment is too short (22.9%), infrequent dose regimen (18.8%), adverse drug incidence (16.9%), and underdose (10.1%).
Co-Authors Delia Komala Sari Dian Handayani Halwa Balqis Mahardika Hendri Saputra Reza Pertiwi Sal Prima Yudha Septi Wulandari