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All Journal Science and Technology Indonesia
Al-Jaber, Afrah A.
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Environmental Science Materials Science & Nanotechnology Physics

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Heterocyclic Azo Compounds, Synthesis, Characterization, Evaluation as Antimicrobial, and Theoretical Study Mohammed, Mohammed K.; Al-Jaber, Afrah A.; Al-Asadi, Rafid H.; Dhaef, Hawraa K.
Science and Technology Indonesia Vol. 11 No. 2 (2026): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2026.11.2.489-501

Abstract

Five azo compounds, including N-(3-hydroxyphenyl) maleimide, were synthesized and characterized using FT-IR, 1H-NMR, 13C-NMR, and mass spectroscopy. The compounds were evaluated for antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa using the disk diffusion method. The screening results showed that the azo compounds tested were effective against the bacteria tested, particularly Staphylococcus aureus. The geometry optimization of the molecular structures and the energy calculations for compounds 1-5 were performed using the density functional approach. Molecular docking was conducted to examine the interaction of the synthesized compound 1 with two bacterial receptors and one viral receptor (neuraminidase). It was found that they would target the PDB:4CJN protein, for which the compound yielded the lowest binding energy.
Co-Authors Al-Asadi, Rafid H. Dhaef, Hawraa K. Mohammed, Mohammed K.