Mashudi, Sugeng
Faculty of Health Science, Universitas Muhammadiyah Ponorogo, Ponorogo

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Corn Silk (Zea mays L.) Extract Is as Effective as Metformin in Reducing Blood Glucose Levels in Diabetic Mice Said, Amanulloh Naufal; Mashudi, Sugeng; Mas’udah, Anni Fithriyatul; Erlisna, Rachel Indah Putri Ayu
Jurnal Penelitian Kesehatan SUARA FORIKES Vol 17, No 2 (2026): February 2026
Publisher : FORIKES

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/sf170209

Abstract

Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia and associated with serious complications affecting multiple organs. The increasing global prevalence of diabetes has encouraged exploration of alternative natural therapies with antihyperglycemic potential. This study aimed to determine the effectiveness of corn silk (Zea mays L.) extract in reducing blood glucose levels in diabetic mice. An experimental study was conducted using two groups of mice, each consisting of six animals. Group I received corn silk extract, while Group II received metformin. Blood glucose levels were measured after treatment, and differences between groups were analyzed using the Mann–Whitney test. Both corn silk extract and metformin reduced blood glucose levels in diabetic mice. Statistical analysis showed no significant difference in the mean reduction of blood glucose levels between the two groups (p = 0.083). Corn silk extract demonstrated a glucose-lowering effect comparable to metformin in diabetic mice, indicating its potential as a natural antihyperglycemic agent.Keywords: corn silk; diabetes mellitus; metformin
Sleep Neurophysiology in the Elderly: The Potential of Brain Gym to Improve Quality of Life Dwirahayu, Yayuk; Mashudi, Sugeng; Irshada, Prima Mulqia
Jurnal Penelitian Kesehatan SUARA FORIKES Vol 17, No 2 (2026): February 2026
Publisher : FORIKES

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/sf170207

Abstract

Sleep disturbances represent a common health problem among older adults due to physiological changes associated with aging, decreased melatonin production, and the presence of chronic diseases. Poor sleep quality has been associated with impaired cognitive function, weakened immune response, increased risk of falls, and reduced overall quality of life. Non-pharmacological interventions such as Brain Gym have been proposed as a potential strategy to improve sleep quality by stimulating the parasympathetic nervous system, enhancing cerebral blood flow, and regulating neurotransmitter activity. This study aimed to examine the effect of Brain Gym on sleep quality among older adults. A quantitative study with a quasi-experimental design using a pretest–posttest control group approach was conducted. The sample consisted of 20 elderly participants selected through purposive sampling based on predetermined inclusion criteria. Brain Gym intervention was administered three times per week for four weeks, with each session lasting 30 minutes. Sleep quality was measured using the Pittsburgh Sleep Quality Index (PSQI) questionnaire. Data were analyzed using the Wilcoxon test to determine differences in sleep quality before and after the intervention. Prior to the intervention, all respondents (100%) were categorized as having poor sleep quality. Following the intervention, eight respondents (80%) demonstrated good sleep quality, while two respondents (20%) remained in the poor category, although their PSQI scores showed improvement. The Wilcoxon test produced a p-value of 0.000 (p < 0.05), indicating a statistically significant difference in sleep quality before and after the intervention. Brain Gym was found to be effective in improving sleep quality among older adults, with an effectiveness rate of 80%. This intervention is simple to implement, safe, and has the potential to be integrated into gerontological nursing care as a non-pharmacological alternative to enhance the quality of life among the elderly.Keywords: brain gym; elderly; neurophysiology; sleep quality; insomnia
Corn Silk (Stigma maydis) Extract Successfully Reduces Blood Glucose Levels in Alloxan-Induced Diabetic Mice Erlisna, Rachel Indah Putri Ayu; Said, Amanulloh Naufal; Mas'udah, Anni Fithriyatul; Mashudi, Sugeng
Jurnal Penelitian Kesehatan SUARA FORIKES Vol 17, No 3 (2026): March 2026
Publisher : FORIKES

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/sf170318

Abstract

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder that requires effective therapeutic strategies with minimal adverse effects. The search for complementary antidiabetic agents derived from natural products has gained increasing attention, particularly those with potential antihyperglycemic activity and favorable safety profiles. Corn silk (Stigma maydis) contains bioactive compounds reported to influence glucose metabolism, making it a promising candidate for adjunctive therapy in T2DM management. This study aimed to evaluate the antihyperglycemic effect of the optimal dose of Stigma maydis ethanol extract (P3) compared with metformin (positive control, K+) in alloxan‑induced hyperglycemic male Swiss Webster mice. Male Swiss Webster mice were induced with alloxan at 150 mg/kgBW to establish a hyperglycemic model. The optimal dose of Stigma maydis extract (P3) and metformin (K+) were administered orally for 14 days. Blood glucose levels were measured before and after treatment. Paired t‑tests were used to assess within‑group changes, while independent t‑tests were applied to compare post‑treatment glucose levels between groups. The P3 group demonstrated a significant reduction in blood glucose levels (p = 0.003), with a post‑treatment mean of 111.40 mg/dL. Although the numerical decrease in the P3 group exceeded that of the metformin group, the difference between groups was not statistically significant (p = 0.576). These findings indicate that the antihyperglycemic activity of Stigma maydis extract is statistically comparable to metformin under the experimental conditions tested. In conclusion, the optimal dose of Stigma maydis ethanol extract produced a significant antihyperglycemic effect in alloxan‑induced mice, with efficacy comparable to metformin. These results support the potential of Stigma maydis as a complementary therapeutic option for T2DM management, warranting further investigation in larger preclinical and clinical studies.Keywords: Stigma maydis; metformin; antihyperglycemic activity