Reconfigurable Intelligent Surfaces (RIS) have emerged as a key enabler for sixth-generation (6G) wireless networks by providing programmable control over the radio propagation environment. However, optimizing RIS configurations in large-scale and dynamic 6G scenarios remains a computationally intensive and non-convex problem, particularly under realistic channel conditions involving user mobility, multi-user interference, and fading effects. This paper proposes a hybrid quantum–classical optimization framework that integrates a Variational Quantum Eigensolver (VQE)–based optimization module with classical iterative solvers to efficiently configure RIS phase shifts and reflection coefficients. The quantum component facilitates probabilistic exploration of the high-dimensional and combinatorial search space associated with large RIS deployments, while the classical component enforces system constraints and ensures convergence stability. Simulation results under realistic 6G channel models demonstrate that the proposed hybrid approach achieves up to 32% faster convergence, 18–25% improvement in spectral efficiency, and notable energy efficiency gains compared to state-of-the-art classical optimization techniques. Furthermore, the framework exhibits scalable performance with increasing RIS element counts and user density, highlighting its suitability for near real-time RIS control under noisy intermediate-scale quantum (NISQ) hardware constraints. These findings indicate that hybrid quantum–classical optimization constitutes a practical and scalable solution for intelligent, adaptive, and energy-efficient RIS-assisted 6G networks.