<![CDATA[Background: Androgenetic alopecia (AGA) is the most common form of progressive hair loss. This disease is known as a polygenic disorder characterized by variability in age of onset, severity and pattern. Genome-wide association studies (GWAS) have shown that variant rs1998076 at locus 20p11 potentially increase the risk factors in Asian and European populations. Association studies between AGA and genetic risks are limited in Indonesian population. Methods: We conducted a cross-sectional pilot study (January-August 2025) in Jakarta, Indonesia, recruiting 100 participants (50 AGA cases and 50 controls). Clinical AGA status was determined by physician. Anthropomorphic data such as height, weight, blood pressure, and smoking history were obtained by measurement and questionnaire. Genotyping of rs1998076 was done by allele-specific PCR method and Sanger sequencing were used to validate the results. Results: Genotype distribution of rs1998076 was AA (24%), GG (37%), and AG (39%). The frequency of allele A of rs1998076 is 0.435, while allele G is 0.565. However, AGA was not significantly correlated with the rs1998076 genotype (p > 0.05) in multivariate models, although GG and AG genotypes showed a tendency for a higher risk of AGA compared to the AA genotype. Conclusion: In this pilot study, rs1998076 was not significantly associated with AGA, although the GG genotype showed a non-significant trend toward higher odds. Clinical factors (age, male sec, higher BMI and hypertension) showed correlations. Larger sample size and well-powered studies are needed to clarify the role of rs1998076 in Indonesians. Keywords: Alopecia; Androgenetic Alopecia;Risk Factor; SNP rs1998076]]>
