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All Journal Pharmascience Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan
Saksono, Reni Yustiati
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Medicine & Pharmacology

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ANALYSIS OF RISK FACTORS AND TREATMENT PHASES ON THE SEVERITY OF HEPATOTOXICITY DUE TO ANTI-TUBERCULOSIS DRUGS Isnani, Nazhipah; hadi, Samsul; Sandi, Dita Aulia Dwi; Rahmatullah, Satrio Wibowo; Adikusuma, Wirawan; Saksono, Reni Yustiati; Auralia, Najma; Maulida, Khelda; Setiawan, Feri
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 11 No 1 (2026): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v11i1.2911

Abstract

Hepatotoxicity caused by anti-tuberculosis drugs (OAT) is one of the adverse effects of tuberculosis therapy and may lead to liver dysfunction. This study aimed to analyze the relationship between age, gender, and treatment phase with the severity of OAT induced hepatotoxicity, as well as to assess factors influencing the increase in hepatotoxicity grade. This research employed a retrospective cross-sectional design and was conducted at Ulin Regional Hospital Banjarmasin using a total sampling method involving 45 tuberculosis patients. Secondary data were obtained from medical records of TB patients in 2024–2025. The results showed that 62.2% of patients were under 60 years old and 37.8% were over 60 years old. Male patients accounted for 75.6%, while females accounted for 24.4%. The distribution of hepatotoxicity grades was 40% normal, 28.9% grade 1, 20% grade 2, and 11.1% grade 3. Based on the treatment phase, 91.1% of patients were in the intensive phase and 8.9% were in the continuation phase. The Chi square test revealed no significant association between age, gender, or treatment phase and the severity of hepatotoxicity.
Antibiotic Use Patterns in Obstetric and Gynecological Surgery Patients: A Quantitative Descriptive Study Using ATC/DDD and DU90% Methods Azzahra, Maryamah; Intannia, Difa; Dwi Sandi, Dita Ayulia; Saksono, Reni Yustiati; Yosita, Revina Aditya; Lingga, Herningtyas Nautika
Journal of Pharmascience Vol 13, No 1 (2026): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v13i1.24199

Abstract

Surgical site infections (SSIs) are common postoperative complications in obstetric and gynecological surgery, with incidence rates up to 20% in cesarean sections. Antibiotics are the primary strategy for SSI prevention; however, antibiotic utilization patterns in this surgical setting remain poorly characterized locally. This study describes the antibiotic use profile, AWaRe classification, DDD/100 patient-days values, and DU90% segment among obstetric and gynecological surgery patients at Ulin Regional General Hospital, Banjarmasin, in 2024. A retrospective, non-experimental quantitative descriptive design was employed. Of 313 medical records reviewed, 137 met the inclusion criteria. A total of 173 antibiotic prescriptions were identified. Ceftriaxone was the most frequently used antibiotic (61.84%), with cephalosporins predominating (91.91%) and parenteral administration in 75.72% of cases. Based on the WHO AWaRe 2022 classification, 85.55% of antibiotics were in the Watch group and 13.29% in the Access group; no Reserve antibiotics were used. Ceftriaxone had the highest DDD/100 patient-days (33.74). Ceftriaxone and cefixime comprised the DU90% segment. These findings highlight a predominance of Watch-group antibiotics and support the need for targeted stewardship interventions
Co-Authors Auralia, Najma Azzahra, Maryamah Difa Intannia Dwi Sandi, Dita Ayulia Herningtyas Nautika Lingga Maulida, Khelda Nazhipah Isnani Rahmatullah, Satrio Wibowo Samsul Hadi Sandi, Dita Aulia Dwi Setiawan, Feri Wirawan Adikusuma Yosita, Revina Aditya