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All Journal Journal Medical Informatics Technology
Nainggolan, Esron
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Computer Science & IT Dentistry Engineering Medicine & Pharmacology Public Health

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Evaluation of Pap Smear Nucleus Cell Image Segmentation: The Impact of Enhancement Processes on Segmentation Result Nainggolan, Esron; Merlina, Nita; Setiadi, Farisya
Journal Medical Informatics Technology Volume 4 No. 1, March 2026
Publisher : SAFE-Network

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37034/medinftech.v4i1.93

Abstract

Accurate nucleus segmentation is vital for automated cervical cancer diagnosis, yet it remains challenging due to overlapping cells and uneven lighting. This study evaluates Polynomial Contrast Enhancement (PCE) using a second-degree polynomial function to improve segmentation on 100 images from the RepomedUNM dataset. The pipeline integrates grayscale conversion, Gaussian blur, and PCE prior to Canny edge detection. Results demonstrate near-perfect Precision (0.9999–1.0000) across all categories (Normal, H-SIL, L-SIL, and Koilocyt), effectively eliminating false positives. However, Recall and Accuracy remained low (max 0.0634 in H-SIL), a technical consequence of Canny’s limitation in capturing thin boundaries versus solid nuclear areas. The study’s novelty lies in the application of second-degree PCE to stabilize intensity variations across multiple diagnostic categories. While PCE ensures exceptional localization precision, future systems should integrate deep learning to enhance recall in complex overlapping structures.
Co-Authors Farisya Setiadi Nita Merlina, Nita