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All Journal Journal of Pharmaceutical and Sciences.
Widodo, Hanifah Nur
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Artikel Tinjauan: Perbandingan Metode KLT, KCKT, dan Spektrofotometri UV-VIS untuk Deteksi dan Kuantifikasi Paraben Pada Kosmetik Widodo, Hanifah Nur; Mulki, Munir Alinu; Ramadhani, Biandra Cinta; Ramadani, Salsabila
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1193

Abstract

Parabens are widely used preservatives in cosmetic products to inhibit microbial growth; however, excessive exposure has been associated with endocrine disruption and skin irritation. This study reviews and compares analytical methods used for the identification and quantification of parabens in cosmetic products, namely Thin Layer Chromatography (TLC), UV–Vis spectrophotometry, and High-Performance Liquid Chromatography (HPLC). Literature searching was conducted through PubMed and Google Scholar for studies published between 2015 and 2025. Ten articles met the inclusion criteria as original research utilizing one of the three analytical methods. TLC is effective for preliminary qualitative identification based on Rf values but is less suitable for quantitative analysis. UV–Vis spectrophotometry allows rapid determination of paraben levels within a λmax range of 254–258 nm and provides reliable results for relatively simple matrices. HPLC generally demonstrates the highest sensitivity, specificity, and accuracy, commonly employing C18 columns, methanol–aquadest mobile phases, retention times of 3–11 minutes, and high linearity (R² ≥ 0.999). Several studies also reported paraben levels exceeding the safety limits established by BPOM RI, highlighting the importance of chromatographic confirmation in cosmetic surveillance. Therefore, the selection of analytical methods should follow a fit-for-purpose approach based on analytical objectives, matrix complexity, and regulatory requirements to ensure product safety.
Artikel Tinjauan: Sediaan Ekstrak Daun Kelor (Moringa oleifera L.) dalam Menurunkan Kadar Glukosa Darah pada Tikus (Rattus norvegicus) yang diinduksi Aloksan Ramadhani, Biandra Cinta; Septiani, Dia; Lismawana, Gita Novianti; Widodo, Hanifah Nur
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1184

Abstract

This study aims to evaluate the effectiveness of Moringa oleifera L. leaf extract preparations in lowering blood glucose levels in alloxan-induced white rats (Rattus norvegicus) through a Systematic Literature Review (SLR) approach. The review process followed the PRISMA 2020 guidelines, with a literature search conducted on the PubMed, ScienceDirect, and Google Scholar databases for the 2015–2025 period. Out of 472 identified articles, nine studies met the inclusion and exclusion criteria for further analysis.The review results indicate that all studies reported a significant decrease in blood glucose levels after the administration of Moringa oleifera leaf extract, both in the form of water extract and ethanol extract. The effective dose used ranged from 200–800 mg/kg body weight, with the highest effectiveness observed at doses of 400–450 mg/kg and an administration duration of 14–28 days. The water extract provided a faster glucose-lowering effect, while the ethanol extract showed more stable and longer-lasting results.The anti-hyperglycemic mechanism of Moringa oleifera leaf extract includes the stimulation of insulin secretion, the protection of pancreatic $\beta$-cells against oxidative stress, and the enhancement of insulin sensitivity in target tissues. The content of flavonoids, saponins, tannins, and chlorogenic acid plays a crucial role in regulating glucose metabolism and increasing antioxidant activity. Overall, this review confirms that Moringa oleifera L. has strong potential as a candidate for a safe and effective natural anti-diabetic phytopharmaca. However, further research with standardized extraction methods and in-depth molecular analysis is still needed to strengthen the scientific basis for its utilization.
Co-Authors Lismawana, Gita Novianti Munir Alinu Mulki Ramadani, Salsabila Ramadhani, Biandra Cinta Septiani, Dia