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Rahmat, Septian Dwi
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Medicine & Pharmacology

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Pharmacokinetic Interaction Between Bay Leaves (Syzygium polyanthum) Infusion and Captopril in Rats Nur, Amran; Rahmat, Septian Dwi; Fiskia, Ermalyanti; Marhamah, Marhamah
Journal of Pharmascience Vol 13, No 1 (2026): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v13i1.23772

Abstract

Captopril, an ACE inhibitor, is commonly prescribed as first-line therapy for hypertension. In practice, patients often combine synthetic drugs with herbal remedies such as bay leaves (Syzygium polyanthum), raising concerns about potential interactions. This study investigated the effect of bay leaves infusion on the pharmacokinetic profile of captopril in white rats (Rattus norvegicus). Ten rats were divided into two groups: group 1 received 25 mg of captopril, while group 2 received the same dose in combination with bay leaves infusion. Blood samples were collected via the tail vein at 0; 0.5; 1; 2; 4; 6; 12 and 24 hours, and analyzed using a UV-VIS spectrophotometer (205 nm). Pharmacokinetic parameters assessed included absorption rate constant (Ka), elimination rate constant (Ke), half-life (t½), peak time (tmax), maximum concentration (Cpmax), and area under the curve (AUC). Results showed that bay leaves infusion increased Cpmax (2.646 → 3.105 µg/ml), prolonged t½ (3.347 → 16.116 h), and elevated AUC (23.382 → 56.479 µg.h/ml). These findings indicate that bay leaves infusion significantly alters the pharmacokinetic profile of captopril.
Co-Authors Amran Nur Ermalyanti Fiskia Marhamah Marhamah