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LAYANAN KESEHATAN BERGERAK UNTUK PEMERIKSAAN PENYAKIT DAN EDUKASI GAYA HIDUP SEHAT DI FLORES TIMUR DAN ENDE Ian Pranandi; Linawati Hananta; Handayani Maria Dara Novi; Dyonesia Ary Harjanti; Felicia Kurniawan; Carmen Claude Margo; Brigitte Leonie Rosadi
Mitramas: Jurnal Pengabdian dan Pemberdayaan Masyarakat Vol. 4 No. 02 (2026): Mitramas, Jurnal Pengabdian dan Pemberdayaan Masyarakat
Publisher : Universitas Katolik Indonesia Atma Jaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/mitramas.v4i02.7388

Keterbatasan akses terhadap pelayanan kesehatan di daerah terpencil seperti Kabupaten Flores Timur dan Kabupaten Ende di Nusa Tenggara Timur menjadi tantangan besar dalam pemenuhan hak dasar masyarakat atas kesehatan. Sebagai respons terhadap hal tersebut, Fakultas Kedokteran dan Ilmu Kesehatan Universitas Katolik Indonesia Atma Jaya bekerja sama dengan Yayasan Ignatius Joseph Kasimo menyelenggarakan kegiatan pengabdian kepada masyarakat dalam bentuk pelayanan kesehatan bergerak selama perayaan Semana Santa 2025. Kegiatan ini tidak hanya bertujuan memberikan layanan pengobatan umum dan edukasi kesehatan secara langsung kepada masyarakat, tetapi juga mendokumentasikan pola penyakit yang sering ditemukan serta melakukan refleksi terhadap sistem pelayanan yang dijalankan. Metode pelaksanaan mencakup kunjungan langsung ke desa-desa terpencil, observasi pelayanan, pencatatan data klinis, dan koordinasi dengan tenaga kesehatan setempat. Hasil kegiatan menunjukkan antusiasme masyarakat yang tinggi serta efektivitas pelayanan berbasis tim medis kecil namun adaptif. Kegiatan ini menegaskan pentingnya kolaborasi multi-sektor dan pendekatan desentralisasi dalam menjangkau komunitas yang terisolasi secara geografis. Artikel ini menjadi kontribusi akademik untuk pengembangan model pelayanan kesehatan komunitas yang kontekstual dan berkelanjutan.

LAYANAN KESEHATAN BERGERAK UNTUK PEMERIKSAAN PENYAKIT DAN EDUKASI GAYA HIDUP SEHAT DI FLORES TIMUR DAN ENDE Ian Pranandi; Linawati Hananta; Handayani Maria Dara Novi; Dyonesia Ary Harjanti; Felicia Kurniawan; Carmen Claude Margo; Brigitte Leonie Rosadi
Mitramas: Jurnal Pengabdian dan Pemberdayaan Masyarakat Vol. 4 No. 02 (2026): Mitramas, Jurnal Pengabdian dan Pemberdayaan Masyarakat
Publisher : Universitas Katolik Indonesia Atma Jaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/mitramas.v4i02.7388

Keterbatasan akses terhadap pelayanan kesehatan di daerah terpencil seperti Kabupaten Flores Timur dan Kabupaten Ende di Nusa Tenggara Timur menjadi tantangan besar dalam pemenuhan hak dasar masyarakat atas kesehatan. Sebagai respons terhadap hal tersebut, Fakultas Kedokteran dan Ilmu Kesehatan Universitas Katolik Indonesia Atma Jaya bekerja sama dengan Yayasan Ignatius Joseph Kasimo menyelenggarakan kegiatan pengabdian kepada masyarakat dalam bentuk pelayanan kesehatan bergerak selama perayaan Semana Santa 2025. Kegiatan ini tidak hanya bertujuan memberikan layanan pengobatan umum dan edukasi kesehatan secara langsung kepada masyarakat, tetapi juga mendokumentasikan pola penyakit yang sering ditemukan serta melakukan refleksi terhadap sistem pelayanan yang dijalankan. Metode pelaksanaan mencakup kunjungan langsung ke desa-desa terpencil, observasi pelayanan, pencatatan data klinis, dan koordinasi dengan tenaga kesehatan setempat. Hasil kegiatan menunjukkan antusiasme masyarakat yang tinggi serta efektivitas pelayanan berbasis tim medis kecil namun adaptif. Kegiatan ini menegaskan pentingnya kolaborasi multi-sektor dan pendekatan desentralisasi dalam menjangkau komunitas yang terisolasi secara geografis. Artikel ini menjadi kontribusi akademik untuk pengembangan model pelayanan kesehatan komunitas yang kontekstual dan berkelanjutan.

Differential Expression Analysis Identifies Novel Regulatory Genes in Endometriosis Ian Pranandi
Jurnal Sehat Indonesia (JUSINDO) Vol. 8 No. 1 (2026): Jurnal Sehat Indonesia (JUSINDO)
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Background: Endometriosis is a chronic estrogen-dependent inflammatory disorder associated with pelvic pain and infertility. Despite its high prevalence, the molecular regulatory mechanisms underlying disease progression remain incompletely understood. Objective: This study aimed to identify differentially expressed genes (DEGs) and prioritize key regulatory candidates involved in endometriosis pathogenesis using integrative bioinformatics analysis. Methods: Publicly available human transcriptomic datasets comparing endometriotic lesions and normal endometrial tissues were analyzed. Data were normalized and subjected to differential expression analysis using adjusted p-value < 0.05 and |log2 fold change| ≥ 1 as thresholds. Functional enrichment analysis and protein–protein interaction (PPI) network construction were performed to identify enriched pathways and hub genes. Results: A total of 326 significant DEGs were identified, including 189 upregulated and 137 downregulated genes. Enrichment analysis revealed predominant involvement of inflammatory signaling, angiogenesis, extracellular matrix remodeling, and steroid hormone response pathways. Network analysis identified IL6, STAT3, VEGFA, and MMP9 as central upregulated hub genes, while PGR and HOXA10 were among the key downregulated regulators associated with progesterone resistance. Conclusion: Endometriosis exhibits coordinated activation of inflammatory–angiogenic networks and suppression of steroid signaling pathways. The identified hub genes represent potential biomarkers and therapeutic targets, warranting further experimental validation.

AI-Assisted Identification of Candidate Diagnostic Biomarkers for Heart Failure Using Multi-Omics Integration Ian Pranandi
Glosains: Jurnal Sains Global Indonesia Vol. 7 No. 3 (2026): Glosains: Jurnal Sains Global Indonesia
Publisher : Sekolah Tinggi Agama Islam Kuningan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59784/glosains.v7i3.843

Background: Heart failure (HF) remains a major global health burden associated with high morbidity and mortality. Conventional biomarkers, such as B-type natriuretic peptide (BNP), have limited diagnostic performance because they do not fully capture the molecular complexity of HF. Integrating multi-omics data with artificial intelligence (AI) may improve the identification of novel diagnostic biomarkers. Objective: This study aimed to identify novel diagnostic biomarkers for HF by integrating transcriptomic and proteomic datasets using AI-assisted machine learning. Methods: Public transcriptomic and proteomic datasets from patients with HF and healthy controls were integrated in an in silico bioinformatics study. Differential expression analysis was performed to identify dysregulated genes and proteins, followed by Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment, and protein–protein interaction (PPI) network analyses. Candidate biomarkers were prioritized using Least Absolute Shrinkage and Selection Operator (LASSO), Random Forest, and Extreme Gradient Boosting (XGBoost). Diagnostic performance was evaluated using receiver operating characteristic (ROC) curve analysis. Results: Multi-omics integration identified 1,247 differentially expressed genes, 186 differentially expressed proteins, and 42 overlapping molecules. Enrichment analyses indicated significant involvement in cardiac remodeling, inflammation, oxidative stress, energy metabolism, and calcium signaling. Five hub biomarkers (NPPB, ATP2A2, IL6, PPARGC1A, and TGFB1) were consistently selected by all machine learning models. Individual biomarkers achieved area under the ROC curve (AUC) values ranging from 0.88 to 0.94, whereas the combined five-biomarker panel achieved an AUC of 0.97, with 92.4% sensitivity and 90.1% specificity. Conclusion: AI-assisted multi-omics integration identified five biologically relevant biomarkers with excellent diagnostic performance, providing a promising foundation for future HF diagnostics and precision cardiology.

Edukasi Interaktif untuk Meningkatkan Pengetahuan Perilaku Hidup Bersih dan Sehat (PHBS) pada Siswa Sekolah Dasar Hananta, Linawati; Pranandi, Ian; Wijayanti, Sri Hapsari; Christian, Yulius Evan; Surya, Junita Elvira Pandji; Veronica, Yellica
CARADDE: Jurnal Pengabdian Kepada Masyarakat Vol. 9 No. 1 (2026): Agustus
Publisher : Ilin Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31960/caradde.v9i1.3378

Clean and Healthy Living Behavior (CHLB) is an essential indicator for creating a healthy school environment and preventing environment-related diseases among elementary school children. Preliminary observations at SDIT Masyarul Huda revealed that students' implementation of CHLB indicators was not yet optimal, particularly regarding proper handwashing with soap, personal hygiene practices, and awareness of the importance of maintaining healthy behaviors within the school environment. These findings served as the basis for implementing an interactive educational program aimed at improving students' knowledge of CHLB indicators. This community service program aimed to improve elementary school students' knowledge of Clean and Healthy Living Behavior (CHLB) indicators in the school setting through an interactive educational approach. The program involved 87 students and employed a one-group pretest–posttest design. Students' knowledge was assessed using a pretest–posttest questionnaire administered before and after the intervention. The educational activities consisted of interactive lectures, group discussions, and handwashing demonstrations. Data were analyzed using the Wilcoxon signed-rank test. The results demonstrated that the proportion of students with good knowledge increased from 33.33% during the pretest to 73.56% during the posttest. The normality test indicated that the data were not normally distributed (p < 0.005); therefore, the Wilcoxon signed-rank test was applied, revealing a statistically significant difference between pretest and posttest knowledge scores (p < 0.005). These findings indicate that interactive education effectively improved students' knowledge of CHLB indicators in the school environment. Furthermore, this approach has the potential to serve as a sustainable school-based health promotion model for fostering clean and healthy living behaviors among elementary school students

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