General Background: Racism is a deeply entrenched social phenomenon shaped by historical, cultural, economic, and political structures. Its manifestations are complex, extending from colonial expansion and the transatlantic slave trade to contemporary institutional discrimination. Specific Background: Existing literature predominantly focuses on racism as a historical consequence or a socio-political issue, yet there remains a need for comprehensive analyses that integrate its structural, ideological, and systemic dimensions. Knowledge Gap: Limited research has explored how economic systems, political structures, and cultural institutions perpetuate racial inequalities, particularly within healthcare, education, and professional environments during crises like COVID-19. Aims: This study employs qualitative and analytical methodologies, including content analysis and critical discourse analysis, to examine the historical foundations and modern implications of racism. Results: Findings reveal persistent ideological structures that reinforce racism, with economic and institutional frameworks sustaining social inequalities. Critical discourse analysis highlights how racist ideologies are embedded within policies and institutional narratives. Novelty: Unlike previous studies, this research integrates historical texts, contemporary sociological data, and intersectional analyses to provide a multi-dimensional perspective on racism’s structural perpetuation. Implications: The study contributes to academic discourse and anti-racism initiatives by offering a deeper understanding of racism’s systemic nature, fostering policy recommendations, and supporting equitable institutional reforms. Highlights: Racism is historically entrenched, influencing institutions and societal structures. Analyzing systemic racism through history, institutions, and discourse. Supports anti-racism policies and equitable institutional reforms. Keywords: Racism, discrimination, race, Origins of Racism, Impact of Racism, Paths to Resolution.