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Askarov T.A
Tashkent State Medical University

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Features of The Disease Management in the Appendical Infiltrate Ismailov F.M.; Dolim K.S; Askarov T.A
Academia Open Vol. 11 No. 1 (2026): June
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.11.2026.13120

Abstract

General Background: Acute appendicitis represents the most prevalent acute abdominal pathology requiring surgical intervention. Specific Background: Appendicular infiltrate, occurring in 1-10% of acute appendicitis cases, poses diagnostic challenges that frequently result in inappropriate treatment selection and unjustified surgical procedures. Knowledge Gap: Despite its clinical significance, standardized diagnostic criteria and management protocols for appendicular infiltrate remain inadequately defined, particularly regarding intraoperative recognition and intervention decisions. Aims: This study analyzed diagnostic approaches and treatment outcomes in patients presenting with appendicular infiltrate to establish evidence-based management protocols. Results: Among 3,567 patients treated for acute appendicitis between 2020-2024, appendicular infiltrate was identified in 38 cases (1.1%). Delayed presentation constituted the primary etiological factor (75%), while atypical appendiceal positioning complicated diagnosis in 7.9% of cases. Conservative management achieved successful resolution in 78.9% of patients, whereas 21.1% required surgical intervention due to abscess formation. Intraoperative identification of infiltrate in six patients necessitated procedure termination with drainage placement; one attempted appendectomy resulted in postoperative complications. Novelty: This investigation establishes that immediate cessation of surgery upon intraoperative infiltrate recognition minimizes complications. Implications: These findings emphasize prioritizing conservative management and avoiding appendectomy when infiltrate is encountered operatively.Highlight : Late patient presentation is the primary factor in the development of appendicular infiltrate. Diagnostic difficulties, including atypical appendix location, often lead to tactical errors. Conservative management is effective in most cases, while unjustified appendectomy increases postoperative complications. Keywords : Acute Appendicitis, Appendicular Infiltrate, Delayed Diagnosis, Conservative Treatment, Surgical Tactics
Quantitative Characterization of Liver Safety in Surgical Diseases and Postoperative Course: Karakterisasi Kuantitatif Keamanan Hati pada Penyakit Bedah dan Perjalanan Pascaoperasi Akhmedov M. Dj; Askarov T.A; Fayziev Y.N.; Ashurmetov A.; Ismailov F. M.
Academia Open Vol. 11 No. 1 (2026): June
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.11.2026.13122

Abstract

General Background: Accurate assessment of liver functional reserve remains critical in surgical practice, as hepatic dysfunction substantially elevates postoperative morbidity and mortality risks. Specific Background: Conventional biochemical markers (ALT, AST, bilirubin) predominantly reflect cytolysis and cholestasis but fail to evaluate hepatocellular energetic status or regenerative capacity. Knowledge Gap: Current diagnostic approaches lack objective quantitative indicators that directly measure mitochondrial function and viable hepatocyte populations in surgical patients. Aims: This study evaluated a novel prognostic coefficient based on the ratio of cytochrome C to TMPD oxidase mitochondrial activities for quantifying liver parenchymal preservation in patients with hepatobiliary surgical diseases. Results: Analysis of 24 patients demonstrated strong inverse correlation between coefficient values and viable hepatocyte percentages. Coefficients of 2.5-3.5 units indicated favorable prognosis, 5-7 units signaled elevated complication risk, while values ≥8 units predicted unfavorable outcomes, irrespective of standard biochemical parameters. Novelty: Unlike traditional markers, this coefficient directly reflects mitochondrial respiratory chain integrity and hepatocellular viability through objective biochemical measurements. Implications: The proposed coefficient serves as an integrated quantitative marker of hepatic functional reserve, enabling improved surgical risk stratification and outcome prediction in hepatobiliary surgery.Highlight : The cytochrome C to TMPD oxidase ratio correlates better with hepatocyte viability than standard biochemical markers in both experimental and clinical contexts. Coefficient values predict postoperative outcomes: 2.5-3.5 units indicate favorable prognosis, 5-7 units suggest complications, and ≥8 units correlate with mortality. Mitochondrial dysfunction demonstrates universal quantifiable patterns across different etiologies, showing consistent relationships between the coefficient and hepatocyte viability. Keywords :Liver Functional Reserve, Mitochondrial Dysfunction, Cytochrome C Oxidase, Hepatocyte Viability, Postoperative Prognosis