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Fayziyev Y.N.
Tashkent State Medical University
Medicine & Pharmacology Public Health

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The Importance of Endolymphatic Administration of Drugs In The Treatment of Persistent Postoperative Peritoniti Ashurmetov A.M.; Usarov A.M.; Fayziyev Y.N.
Academia Open Vol. 11 No. 1 (2026): June
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.11.2026.13140

Abstract

Persistent postoperative peritonitis remains a major challenge in abdominal surgery due to high rates of septic complications, antimicrobial resistance, and insufficient drug concentrations at the site of inflammation, making optimization of regional drug delivery clinically relevant. This study aims to evaluate the clinical and immunological effectiveness of endolymphatic drug administration in the comprehensive treatment of appendicular peritonitis. A retrospective and comparative clinical study was conducted on 66 patients with appendicular peritonitis treated in surgical departments of Tashkent city clinics, divided into a main group receiving endolymphatic therapy and a control group managed with conventional treatment. Clinical severity scores, biochemical parameters, intoxication indices, and immunological markers were analyzed using non-parametric statistical methods. The results demonstrate that endolymphatic drug administration achieved higher local therapeutic concentrations, significantly improved lymphocyte subpopulations, enhanced humoral immunity indicators, reduced endogenous intoxication, and accelerated recovery compared with standard therapy. Unlike prior studies that focused primarily on systemic antibiotic regimens, this research provides empirical evidence on the immunomodulatory and detoxifying advantages of targeted endolymphatic therapy in postoperative peritonitis. These findings contribute to the theoretical understanding of lymphatic system involvement in inflammatory control and support practical and policy-oriented implications for integrating endolymphatic drug administration into surgical infection management protocols to reduce complications and improve patient outcomes.Keywords : Endolymphatic antibiotic therapy, appendicular peritonitis, immunomodulation, lymphatic drug delivery, surgical sepsis prevention, postoperative complicationsHighlight : Endolymphatic therapy increases total T-lymphocytes 1.41-fold and improves immunoglobulin levels significantly. Neutrophil phagocytic activity rises 1.68-fold in treated patients versus minimal improvement in controls. The intervention normalizes microcirculation and enhances lymph transport into bloodstream effectively.
Endolymphatic Drug Delivery Improves Outcomes in Persistent Postoperative Peritonitis Usarov A.M.; Ashurmetov A.M.; Fayziyev Y.N.
Academia Open Vol. 11 No. 1 (2026): June
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.11.2026.13141

Abstract

Postoperative peritonitis remains a critical challenge in contemporary surgery, with persistent complications despite conventional antibiotic therapy leading to increased mortality and prolonged recovery periods. This study investigates the therapeutic efficacy of direct endolymphatic drug therapy (TTBET) in managing persistent postoperative peritonitis following acute appendicitis. The research examined 66 patients with appendicular peritonitis treated in Tashkent surgical clinics, divided into a main group receiving endolymphatic therapy via catheterized peripheral lymphatic vessels (n=36) and a control group receiving conventional treatment (n=30). Immunological parameters including T-lymphocytes, B-lymphocytes, immunoglobulins (IgG, IgA, IgM), and neutrophil phagocytic activity were measured at baseline and day 14 post-treatment using standardized biochemical and immunological assays. Results demonstrated statistically significant improvements in the endolymphatic therapy group, with T-lymphocyte counts increasing 1.41-fold compared to controls (p=0.0022), IgG levels rising 1.7-fold versus 1.49-fold in controls, and neutrophil phagocytic activity improving 1.68-fold versus negligible change in the control group. This study provides novel evidence that endolymphatic administration achieves superior drug concentration at inflammatory sites while simultaneously modulating immune responses through direct lymphatic system engagement. The findings suggest endolymphatic therapy represents a pathogenetically sound approach for managing persistent peritonitis, offering reduced antibiotic doses, enhanced immunological recovery, and improved clinical outcomes, warranting broader clinical implementation in surgical infection management protocols.Keywords : Endolymphatic Drug Administration, Postoperative Peritonitis Management, Lymphatic System Therapeutics, Immunomodulation Surgical Infections, Regional Antibiotic Delivery, Purulent-Septic ComplicationsHighlight : Endolymphatic therapy significantly increases T-lymphocytes, immunoglobulins IgG/IgM, and neutrophil phagocytic activity Main group shows 1.41-fold T-lymphocyte increase versus minimal improvement in control group Treatment normalizes microcirculation and reduces postoperative complications in appendicular peritonitis patients.
Co-Authors Ashurmetov A.M. Usarov A.M.