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All Journal Indonesian Journal Health Science and Medicine Academia Open
Suhad Khalid Sgheer
Directorate of Education of Kerbala, Ministry of Education, Kerbala
Health Professions Medicine & Pharmacology Public Health Veterinary

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Lactoferrin on Physiological Characteristics and Intestinal Microorganisms in Anemic Rats Suhad Khalid Sgheer; Tuqa Sabbar Rahi
Academia Open Vol. 11 No. 1 (2026): June
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.11.2026.13267

Abstract

General Background: Iron is essential for hematopoiesis, immune competence, and growth, and its deficiency leads to anemia with systemic consequences. Specific Background: Lactoferrin, an iron-binding glycoprotein, exhibits hematopoietic, immunomodulatory, and antimicrobial activities that may benefit anemia and gut microbiota balance. Knowledge Gap: Experimental evidence comparing purified and commercial lactoferrin on hematological indices and intestinal microbial populations in anemic models remains limited. Aims: This study evaluated the effects of purified and commercial lactoferrin on blood parameters and gut microorganisms in anemic female rats. Results: Lactoferrin administration increased red blood cells, hemoglobin, and platelets, reduced white blood cell counts, enhanced lactic acid bacteria, and decreased coliforms, Staphylococcus spp., and Enterococcus spp., with strongest effects at 30 µg/kg purified lactoferrin, while Salmonella showed minimal change. Novelty: The study demonstrates dose-dependent superiority of purified lactoferrin over commercial forms. Implications: Purified lactoferrin represents a promising dietary supplement for anemia management and gut health modulation.Keywords : Lactoferrin, Iron Deficiency Anemia, Hematological Parameters, Gut Microbiota Modulation, Female Albino RatsHighlight : Purified supplementation significantly increased erythrocyte, hemoglobin, and platelet indices in anemic female models. Dose-dependent treatment reduced leukocyte counts, indicating pronounced immunomodulatory activity. Beneficial gut bacteria increased, while coliforms, staphylococci, and enterococci declined after intervention.
Biosynthesized Silver Nanoparticles Demonstrate Hepatoprotective Biochemical Safety in Female Wistar Rats Suhad Khalid Sgheer; Ali Tariq Abdul Hassan
Indonesian Journal on Health Science and Medicine Vol. 2 No. 3 (2025): Desember
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i3.350

Abstract

General Background: Silver nanoparticles (AgNPs) are widely applied in biomedical and technological fields, yet conventional chemical and physical synthesis methods raise safety and environmental concerns. Specific Background: Biosynthesis using probiotic bacteria such as Lactobacillus rhamnosus has emerged as a green alternative with potential biocompatibility advantages. Knowledge Gap: Limited in vivo evidence exists regarding the biochemical and histological safety of biosynthesized AgNPs, particularly their hepatic effects. Aims: This study aimed to evaluate the biochemical and histological effects of AgNPs biosynthesized by L. rhamnosus in female Wistar albino rats. Results: Biosynthesized AgNPs significantly reduced liver enzymes (ALT, AST, and ALP), significantly increased vitamin B12 levels, showed no significant change in body weight, and preserved normal liver tissue architecture. Novelty: The study demonstrates the hepatic safety profile of L. rhamnosus–mediated AgNPs in vivo compared with risks reported for conventionally synthesized AgNPs. Implications: These findings support probiotic-mediated biosynthesis as a safer and environmentally friendly approach for developing silver nanoparticles for biomedical applications.Keywords : Biosynthesized Silver Nanoparticles, Lactobacillus rhamnosus, Green Nanoparticle Synthesis, Liver Enzyme Biomarkers, Wistar Albino RatsHighlight : Significant reductions in AST, ALT, and ALP without alterations in body mass. Serum vitamin B12 concentrations increased markedly following 30-day administration. Liver histology preserved normal architecture, indicating absence of hepatocellular damage.
Co-Authors Ali Tariq Abdul Hassan Tuqa Sabbar Rahi