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Riyam Wissam Hassan
Department of Health Management Techniques, Polytechnic College/Al–Qadisiyah, Al-Furat Al- Awsat Technical University
Medicine & Pharmacology Public Health

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Isolation and Antibiotic Susceptibility Patterns of Pseudomonas aeruginosa From the Patients with Respiratory Tract Infection Riyam Wissam Hassan
Academia Open Vol. 11 No. 1 (2026): June
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.11.2026.13356

Abstract

General Background: Respiratory tract infections caused by bacterial pathogens contribute significantly to global morbidity and mortality, with Pseudomonas aeruginosa being a major nosocomial pathogen frequently isolated from respiratory infections. This Gram-negative bacterium exhibits intrinsic antibiotic resistance and can develop multiple resistance mechanisms, making treatment increasingly challenging. Knowledge Gap: Although P. aeruginosa is recognized for multidrug resistance, periodic monitoring of antibiotic susceptibility patterns in specific geographic regions remains essential as resistance profiles vary temporally and geographically. Aims: This study aimed to isolate and identify P. aeruginosa from sputum samples of patients with respiratory tract infections and determine antibiotic susceptibility patterns against thirteen commonly used antibiotics. Results: Among 110 sputum samples collected from Al-Diwaniyah Teaching Hospital (March-July 2025), P. aeruginosa was isolated from 33.33% of culture-positive samples, demonstrating highest resistance to ceftazidime (76.92%), cefepime (73.07%), and levofloxacin (76.92%), while showing greater sensitivity to amikacin (61.53%) and colistin (53.84%). Novelty: This investigation provides current antibiotic resistance data specific to the Al-Diwaniyah region, revealing alarmingly high resistance rates to modern-generation cephalosporins. Implications: These findings necessitate updating regional antibiotic treatment protocols for respiratory infections and recommend amikacin-colistin combination therapy to mitigate further resistance development.Keywords : Pseudomonas Aeruginosa, Antibiotic Resistance, Respiratory Tract Infections, Antimicrobial Susceptibility, Multidrug ResistanceHighlight : P.aeruginosa accounted for 33.33% of bacterial respiratory tract infections studied. Highest resistance observed to Ceftazidime (76.92%), Levofloxacin (76.92%), and Cefepime (73.07%). Amikacin and Colistin demonstrated greatest effectiveness with 61.53% and 53.84% sensitivity rates.
Antibiotic Resistance Patterns of Pseudomonas aeruginosa in Respiratory Infections: Polanya Resistensi Antibiotik Pseudomonas aeruginosa pada Infeksi Pernafasan Riyam Wissam Hassan
Academia Open Vol. 11 No. 1 (2026): June
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.11.2026.13542

Abstract

General Background: Respiratory tract infections remain a major cause of morbidity worldwide and are frequently associated with bacterial pathogens. Specific Background: Pseudomonas aeruginosa is a prominent hospital-acquired pathogen known for its multidrug resistance, complicating therapeutic management. Knowledge Gap: Local and time-specific data on antibiotic susceptibility patterns of P. aeruginosa in respiratory infections remain limited. Aims: This study aimed to isolate and identify P. aeruginosa from sputum samples of patients with respiratory tract infections and to evaluate its antibiotic susceptibility patterns. Results: Out of 110 sputum samples, 78 showed bacterial growth, with P. aeruginosa identified in 26 samples (33.33%). High resistance rates were observed for cephalosporins, particularly ceftazidime (76.92%) and cefepime (73.07%), as well as levofloxacin (76.92%). Moderate resistance was noted for carbapenems, while higher sensitivity was recorded for amikacin (61.53%) and colistin (53.84%). Novelty: The study provides recent localized data on resistance profiles of P. aeruginosa in Al-Diwaniyah Governorate. Implications: These findings support evidence-based antibiotic selection and highlight the necessity for continuous surveillance to guide effective treatment strategies and limit antimicrobial resistance. Keywords: Pseudomonas Aeruginosa, Respiratory Tract Infections, Antibiotic Resistance, Sputum Samples, Antimicrobial Susceptibility Key Findings Highlights: Pseudomonas aeruginosa accounted for one-third of culture-positive respiratory samples. High resistance was observed against third- and fourth-generation cephalosporins. Amikacin and colistin showed comparatively higher susceptibility rates.
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