Article Per Year (5 Year)
p-Index From 2021 - 2026
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All Journal Jurnal Farmasi Sains dan Komunitas Jurnal Farmasi Galenika (Galenika Journal of Pharmacy)
Eka Indra Setyawan
Udayana University
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

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The The Pharmacokinetics of Single-Inhaler Triple Therapy: A Systematic Review: Farmakokinetika Inhaler Tunggal Tiga Komponen: Ulasan Sistematis Sang Ayu Made Arenawati; I Nyoman Dwika Dharmanta; Made Ary Sarasmita; Eka Indra Setyawan; Luh Putu Mirah Kusuma Dewi
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 12 No. 1 (2026): (March 2026)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2026.v12.i1.17960

Abstract

Background: The integration of inhaled corticosteroids, long-acting -agonists, and long-acting muscarinic antagonists into a fixed-dose Single Inhaler Triple Therapy (SITT) represents a pivotal strategy for managing chronic obstructive pulmonary disease (COPD) in patients with persistent symptomatology or frequent exacerbations. Despite the proven clinical efficacy of SITT, data regarding its pharmacokinetic properties across both healthy volunteers and the COPD population appear disjointed, warranting a comprehensive synthesis. Methods: We executed a systematic review following the PRISMA 2020 framework. A rigorous search of electronic databases was undertaken to retrieve clinical and population pharmacokinetic trials examining SITT. Articles were screened against specific inclusion criteria, and methodological quality was scrutinised using standard risk-of-bias instruments. Data synthesis was performed narratively, prioritizing essential pharmacokinetic indicators. Results: The review consolidated data on key metrics, specifically peak plasma concentrations, total systemic exposure, and time to peak. The analysis revealed that systemic bioavailability of the triple combination components is bioequivalent to that of their respective mono- or dual-therapy formulations. Furthermore, no significant drug accumulation was detected following multiple doses. Variations in pharmacokinetic behavior were predominantly linked to patient demographics, disease severity, and inhaler handling proficiency. Conclusion: SITT exhibits a consistent and predictable pharmacokinetic profile characterized by low systemic exposure in both healthy individuals and patients with COPD. These insights reinforce the pharmacological stability and therapeutic viability of single-inhaler regimens in clinical practice.
A Decade of Research about Honey as an Antioxidant in the Scopus Database: Bibliometric Analysis Eka Indra Setyawan; Komang Dian Aditya Putra; Izzul Ishfahan; Gek Niken Tasya Lingling
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 1 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.007378

Abstract

Honeybees transform flowers' delicious, aromatic, and viscous nectar into the naturally occurring, antioxidant-rich honey. A growing scientific study increasingly supports honey's use in complementary and alternative medicine. No bibliometric analysis of published data on honey antioxidants has been conducted to ascertain the state of the research. Using VOSviewer and RStudio, we conducted a bibliometric analysis of the scholarly articles about honey's antioxidants in the Scopus database. Honey's antioxidant properties were covered in 765 papers between 2013 and 2023. Most publications (309 articles) are attributed to Malaysian researchers, with Universiti Sains Malaysia being the most productive, with 53 articles produced. Food Chemistry is the most productive source, with an average of 64.8 citations per article and 24 documents. Having the highest H-index of 10, Battino M significantly influenced the honey's antioxidant properties studies. "Honey" and "antioxidant activity" were the most frequent keywords. We can learn about the novelty of honey as an antioxidant research from this results.
Co-Authors Gek Niken Tasya Lingling I Nyoman Dwika Dharmanta Izzul Ishfahan Komang Dian Aditya Putra Luh Putu Mirah Kusuma Dewi Made Ary Sarasmita Sang Ayu Made Arenawati