<![CDATA[Thyroid disease is a common endocrine disorder that can cause serious metabolic and cardiovascular complications, so accurate early detection is clinically essential. This study proposes a Support Vector Machine (SVM) classifier enhanced with Recursive Feature Elimination (RFE) to select the most informative attributes and Adaptive Synthetic Sampling (ADASYN) to handle class imbalance in a Kaggle thyroid dataset of 3,771 clinical records. The data contain 25 diagnostic attributes with a strongly skewed distribution between healthy and thyroid cases. The model’s robustness was examined using three train–test split ratios. The best configuration, SVM with a Linear kernel and 20 RFE-selected features under an 80:20 split, achieved 98.39% accuracy, with precision, recall, and F1-score all reaching 0.98, indicating consistently strong performance across classes. RFE contributes by removing redundant or weakly relevant variables, helping the classifier construct a more stable and interpretable decision boundary. ADASYN further improves the representation of the minority class, yielding higher recall and F1-score for thyroid cases and reducing the risk of missed diagnoses. Overall, the combined use of feature selection and adaptive oversampling produces a balanced and computationally efficient model for thyroid disease classification. These findings suggest that the proposed approach can support clinical decision-making, reduce diagnostic errors in imbalanced data settings, and strengthen early detection efforts in endocrine health assessment. By offering high sensitivity for thyroid cases while maintaining robust specificity for healthy patients, the model is well suited for integration into clinical decision-support and routine screening workflows.]]>
