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All Journal Biology, Medicine, & Natural Product Chemistry
Tanti Agustina
Universitas Gadjah Mada
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health

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The Relationship Between Total IgE, Symptom Duration, VAS Scores, and Danyoung Classification in Allergic Rhinitis Ayunita Tri Wirattami; Tanti Agustina
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.957-960

Abstract

Allergic Rhinitis (AR) is an inflammatory condition of the nasal mucosa triggered by allergies, with total IgE often used as a biomarker to assess disease severity. Objective: To analyze the relationship between total IgE levels, symptom duration, Visual Analog Scale (VAS) scores, and Danyoung Classification in AR patients. Methods: A cross-sectional observational analytical study was conducted on 73 patients at the Allergy-Immunology Clinic of Dr. Saiful Anwar General Hospital. Total IgE levels were measured using the ELISA method, while VAS and nasal mucosa classification were assessed through anamnesis and nasoendoscopy. Results: The study showed68.5% of patients had IgE levels above 100 IU/ml, with an average of 982.97 IU/ml. Although higher IgE levels were often found in AR patients, there was no statistically significant correlation between IgE levels and Danyoung classification (significance value 0.924). The correlation test showed a coefficient of -0.11, indicating a negative correlation, but it was not statistically significant. Conclusion: The nasal mucosa condition in patients with high IgE levels does not always reflect severe inflammation. In addition to IgE levels, external factors such as exposure to pollutants and cigarette smoke also play a role in the condition of the nasal mucosa. Therefore, while high IgE levels often indicate allergic reactions, this study found no significant relationship between IgE levels and AR severity.
The Correlation Between Sinonasal Outcome Test (SNOT)-22 and Modified Lund-Kennedy (MLK) in Chronic Rhinosinusitis (CRS) Patients Iriana Maharani; Crashana Siregar; Tanti Agustina
Biology, Medicine, & Natural Product Chemistry Vol 15, No 1 (2026)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2026.151.881-884

Abstract

CRS is an inflammation of the sinonasal mucosa. SNOT-22 is a questionnaire that assesses the life quality of CRS patients. MLK is a scoring system that uses nasal endoscopy. This study aims to analyze the correlation between complaints on SNOT-22 and endoscopy findings on MLK. This cross-sectional study was conducted at a tertiary hospital from January 2023 to December 2024. A total of 74 patients were included: 45 CRS with Nasal Polyps (CRSwNP) and 29 CRS without Nasal Polyps (CRSsNP). This study used Pearson’s statistical analysis to identify the correlation between SNOT-22 and MLK in CRS patients, more specifically in CRSwNP and CRSsNP with Spearman’s statistical analysis. There is a correlation between SNOT-22 and MLK in CRS with r=0.408, sig/p value 0.000<0.05; a correlation in CRSwNP with r=0.364, sig/p value 0.014<0.05; a correlation in CRSsNP with r=0.482, sig/p value 0.008<0.05; a correlation between SNOT-22 nasal phase and MLK in CRSwNP with r=0,876, sig/p value=0,000<0,05; and no correlation between SNOT-22 nasal phase and MLK in CRSsNP with r=0,345, sig/p value 0.066>0.05. There is a moderate correlation between SNOT-22 and MLK in CRS, a weak correlation in CRSwNP, a moderate correlation in CRSsNP, a very strong correlation between SNOT-22 nasal phase and MLK in CRSwNP, and no correlation between SNOT-22 nasal phase and MLK in CRSsNP.
Co-Authors Ayunita Tri Wirattami Crashana Siregar Iriana Maharani