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All Journal African Multidisciplinary Journal of Sciences and Artificial Intelligence African Journal of Biochemistry and Molecular Biology Research
Ujong Peter Ujong
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Environmental Science Materials Science & Nanotechnology

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Telfairia occidentalis Ameliorates Streptozotocin-induced Testicular Oxidative stress by Restoring Endogenous Antioxidant Enzyme Activity and Inhibiting Apoptosis, and Pro-inflammatory cytokines Ujong Peter Ujong; Edward Emuru Odey
African Multidisciplinary Journal of Sciences and Artificial Intelligence Vol 1 No 2 (2024): African Multidisciplinary Journal of Sciences and Artificial Intelligence
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/amjsai.v1i2.3800

Abstract

The study investigated the protective role of Telfairia occidentalis (TO) against Streptozotocin-induced testicular damage in male Wistar rats, by observing the levels of prooxidants, endogenous antioxidant enzymes inflammatory biomarkers, as well as apoptotic proteins. Thirty-five animals were used for this study and shared into five groups of seven animals each. Group 1 (normal control) received distilled water throughout the experiment. Groups 2-5 received 10% fructose ad libitum for 14 days followed by a single injection of 40 mg/kg body weight streptozotocin, intraperitoneally. After confirmation of diabetes mellitus, group 2 rats received 0.5ml distilled water, group 3 received TO (200 mg/kg body weight), group 4 received TO (300 mg/kg body weight) and group 5 received Metformin (300 mg/kg body weight). All treatments lasted for 28 days, followed by the sacrifice of all experimental animals and the harvest of their testes for biochemical analyses. Results revealed that streptozotocin administration decreased the activities of the antioxidant enzymes SOD, GSH, GST, GPx, CAT while elevating MDA levels in groups 2-5 animals when compared with group 1. Treatment with TO showed increased activities of antioxidant enzymes and reduced MDA levels. Furthermore, streptozotocin administration increased the levels of the inflammatory biomarkers MPO, IL-1β, TNF-α, iNOS, COX-2, and the apoptotic protein, caspase-3 in groups 2-5 animals when compared with group 1. However, these elevations were reversed by the administration of TO. In conclusion, Telfairia occidentalis demonstrates significant protective effects on the antioxidant status and inhibits oxidative stress markers, and inflammatory cytokines in the testes of diabetic rats. This indicates its potential therapeutic value in mitigating diabetes-related testicular complications through the modulation of oxidative stress and inflammatory pathways.
Bifenthrin Causes Kidney Damage via Induction of Oxidative Stress, Activation of Pro-Inflammatory Cytokines, and Up-Regulation of Apoptosis in Wistar Rats Ujong Peter Ujong; Mbang Edet Ibor
African Journal of Biochemistry and Molecular Biology Research Vol 1 No 1 (2024): African Journal of Biochemistry and Molecular Biology Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajbmbr.v1i1.3654

Abstract

This study investigated the role of oxidative stress, inflammation, and apoptosis in bifenthrin-induced kidney damage in Wistar rat models. Adult male rats (110-300g) were divided into three groups of 10 rats each. Group 1 served as the normal control, while groups 2-3 were orally given 1 mg/ kg body weight bifenthrin for 14 and 28 days respectively. The results revealed that bifenthrin administration caused a significant (p<0.05) decrease in renal antioxidant enzymes such as superoxide dismutase, catalase, glutathione, glutathione S-transferase, and glutathione peroxidase. Conversely, malondialdehyde levels were significantly (p<0.05) increased. Pro-inflammatory cytokines TNF-α, IL1-β, IL-6, COX-2, iNOS, LTE B4, and PGE2 were significantly (p<0.05) elevated, highlighting an inflammatory response. Additionally, the apoptotic markers, caspase-3, and BAX were significantly (p<0.05) increased, while BCL-2, an anti-apoptotic protein, was significantly (p<0.05) decreased, indicating enhanced apoptosis. Renal function markers, creatinine, and urea were also significantly (p<0.05) elevated in bifenthrin-induced groups. Furthermore, the histopathology results revealed morphological damages in the kidneys of groups 2 and 3 animals These findings demonstrate bifenthrin's potential to cause significant oxidative stress, inflammation, apoptosis, and structural damage in renal tissues.
Co-Authors Edward Emuru Odey Mbang Edet Ibor