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All Journal African Journal of Biochemistry and Molecular Biology Research African Journal of Sciences and Traditional Medicine
Saleem Sule Zarto
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Nursing Public Health

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Antimycobacterial Activity of Newbouldia laevis Root and Stem Bark Extracts: In Vitro Evaluation and Phytochemical Composition Saleem Sule Zarto; Sa'ad Sabri Abdul; Joseph F. Kpesibe; Saminu Hamman Barau
African Journal of Biochemistry and Molecular Biology Research Vol 1 No 1 (2024): African Journal of Biochemistry and Molecular Biology Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajbmbr.v1i1.3311

Abstract

This present study aimed to determine the phytochemical screening, antimicrobial and anti-tuberculosis activity of the root and stem bark of methanol extracts of the N. laevis plant from Gashaka Gumti national park of Taraba state. Phytochemical screening was carried out using standard methods. For the two extracts obtained from the root and stem bark which revealed the presence of all except cardiac glycosides and quinones in the root, while all were the stem bark extracts. The Anti-bacterial assay was carried out using Agar-well diffusion technique. The highest zone of inhibition for the root crude extract of E. coli was (18mm) and its lowest zone of inhibition was (2mm), the highest zone of inhibition of Stap. A was (22mm) and the lowest was (8mm), the highest zone of inhibition of Bacillus cereus (22mm) and its lowest was (10mm). Salmonella typhii had the highest zone of inhibition for the root extract at (24mm) and its lowest at (4mm). The highest zone of inhibition for stem bark crude extract of E. coli was (12mm) and its lowest zone of inhibition was (5mm), the highest zone of inhibition of Stap. A was (13mm) and the lowest was (6mm), the highest zone of inhibition of Salmonella typhii was (18mm) and its lowest was (18mm),the highest zone of inhibition of Bacillus cereus (12mm) and its lowest was (4mm). The anti- tuberculosis assay was carried out using Broth micro dilution method. The result concerning the mycobacterium TB (anti-tuberculosis) of the root and stem bark crude extract of N. laevis plants inhibit the growth of bacterium with inhibitory zone within the range 6-16mm. This study reveals that the methanolic crude extract of N. laevis root and stembark can be utilized as a potential anti-tuberculosis (TB) drug for novel discovery.
Phytochemical Analysis, Anti-Microbial and Anti-Tuberculosis Activities of Methanol Extract of Piliostigma Thonnigii Leaves Extract Daniel W. Malgwi; Saleem Sule Zarto; Rakiya D. Adamu; Farimani B. Dowell
African Journal of Sciences and Traditional Medicine Vol 1 No 1 (2024): African Journal of Sciences and Traditional Medicine
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajstm.v1i1.3359

Abstract

The purpose of this study is to evaluate the antibacterial, anti-tuberculosis, and phytochemical screening properties of a crude extract of P. thoningii leaves from the Girei local government area in Adamawa state, Nigeria. Standard procedures were used for phytochemical screening, and the disc diffusion method was used for evaluations of antibacterial sensitivity and anti-tuberculosis activity. When leaves extract was screened phytochemically, alkaloids, flavonoids, phenol, terpenoid, quinone, and resins were found, but tannin and saponins were not. The greatest concentration of 500 ug/ml was used to evaluate the antibacterial activity against various pathogens. The results indicated that the zone of inhibition for E. Coli was 19 mm, for Staphyloccocus aureu it was 17 mm, for Salmonella typhi it was 20 mm, for Klabsiella pneumonia it was 26 mm, and for pseudomonas it was 22 mm. With a positive control of streptomycine, 30 ug at 28 mm inhibitory zone, anti-tuberculosis activity shown that the bacteria growth was suppressed at different concentrations of 500 ug/ml (12 mm), 250 ug/ml (9 mm), 125 ug/ml (8 mm), and 6.25 ug/ml (7 mm) growth. This study highlights the P. thoningii plant's potential as a source for the development of anti-tuberculosis (TB) drugs.
Co-Authors Daniel W. Malgwi Farimani B. Dowell Joseph F. Kpesibe Rakiya D. Adamu Sa'ad Sabri Abdul Saminu Hamman Barau