Article Per Year (5 Year)
p-Index From 2021 - 2026
0.23
P-Index
This Author published in this journals
All Journal African Journal of Biochemistry and Molecular Biology Research
Chidiebere U
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
Mitigating Alcohol-Induced Liver Enzyme Alterations in Wistar Rats Through Forced Swimming Exercise Abdul-Kareem Y. I; Chidiebere U; Yilgwan G; Usman Y. M; Galam N. Z
African Journal of Biochemistry and Molecular Biology Research Vol 1 No 1 (2024): African Journal of Biochemistry and Molecular Biology Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajbmbr.v1i1.3703

Abstract

This study investigates the impact of forced swimming exercise on alcohol-induced alterations in hepatic enzyme biomarkers in Wistar rats (mean weight 150-200g). Twenty Wistar rats were randomly divided into four groups of five rats each: a normal control group, an exercise-only group, an alcohol-only group, and an exercise plus alcohol group. The control group received 0.9% normal saline 5 days a week for 12 weeks. The exercise group underwent forced swimming for 5 minutes a day, 5 days a week, for 12 weeks. The alcohol group received 20% ethanol orally at a dose of 2.0g/kg body weight. The combined exercise and alcohol group followed the same protocols as the exercise and alcohol groups. At the end of the 12-week period, all animals were euthanized, and blood samples were collected for analysis of hepatic enzyme biomarkers, including ALT, AST, and GGT, using an automated serum biochemistry analyzer. Results showed significant elevation of hepatic enzyme biomarkers in the alcohol-only group, while the normal control, exercise-only, and exercise plus alcohol groups exhibited decreased enzyme levels. These findings indicate that exercise mitigates alcohol-induced liver enzyme alterations in adult male Wistar rats. The study suggests that exercise training may be effective in alleviating liver damage from chronic alcohol consumption and could potentially prevent liver failure and hepatocellular carcinoma.
Co-Authors Abdul-Kareem Y. I Galam N. Z Usman Y. M Yilgwan G