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All Journal African Journal of Biochemistry and Molecular Biology Research
Lazarus Joseph Goje
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology

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Determination of Mechanism of Resistance to Pyrethroid by Anopheles gambiae sensu lato from Gombe State, Nigeria Asama’u Yusuf; Lazarus Joseph Goje; Simon Gabriel Mafulul; Nabiha Garba; Nura Abubakar
African Journal of Biochemistry and Molecular Biology Research Vol 2 No 1 (2025): African Journal of Biochemistry and Molecular Biology Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajbmbr.v2i1.5023

Abstract

The emergence of insecticide resistance in Anopheles gambiae sensu lato poses a significant challenge to malaria control efforts, particularly in endemic regions like Gombe, Nigeria. This study aimed to investigate the mechanisms underlying pyrethroid resistance and identify the prevalent Anopheles species in the area. Morphological identification was performed using keys from Gille and Coetzee, confirmed by molecular techniques employing SINE200 PCR for precise species characterization. The results revealed that the An. gambiae complex comprised 75% of the mosquito population, indicating its dominance in the region. Knockdown rate bioassays demonstrated a time-dependent increase in resistance to insecticides, with notable exceptions observed with deltamethrin. Susceptibility testing conducted 24 hours post-exposure confirmed that the population exhibited resistance to all tested insecticides, with DDT showing the highest resistance level. Molecular analysis identified Anopheles coluzzii as the most prevalent species in Gombe, followed by An. arabiensis. Additionally, the prevalence of kdr alleles was assessed, revealing a significant correlation between the L1014F mutation and resistance phenotypes. Specifically, the frequency of the L1014F allele was linked to increased resistance levels, while the homozygous susceptible allele was also prevalent, suggesting the potential influence of other resistance mechanisms. In conclusion, this study highlights the critical need for ongoing surveillance of insecticide resistance in Anopheles gambiae populations. It underscores the importance of understanding the genetic basis of resistance to inform effective vector control strategies. The findings emphasize that adaptive management of insecticide use, considering the dynamics of resistance and species composition, is essential for enhancing malaria control efforts in Gombe and similar regions.
The Role of Telomeres and Telomerase in Cellular Aging and Disease: Mechanisms, Implications, and Therapeutic Interventions Grace Christopher; Lazarus Joseph Goje
African Journal of Biochemistry and Molecular Biology Research Vol 2 No 2 (2025): African Journal of Biochemistry and Molecular Biology Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajbmbr.v2i2.5151

Abstract

Telomeres, the protective caps at the ends of chromosomes, play a crucial role in maintaining genomic stability. This review explores the structure and function of telomeres, the mechanisms of telomere shortening, and the role of telomerase in counteracting this process. Telomere shortening is a natural consequence of cell division and is associated with cellular aging, senescence, and apoptosis. The review delves into the molecular biology of telomeres, highlighting the significance of the shelterin complex in protecting telomeres from degradation and fusion. It also discusses the genetic and epigenetic factors influencing telomere length, the impact of oxidative stress and inflammation on telomere attrition, and potential interventions to preserve telomere length. The review concludes with recommendations for lifestyle changes and therapeutic strategies to mitigate telomere shortening and promote healthy aging.
Co-Authors Asama’u Yusuf Grace Christopher Nabiha Garba Nura Abubakar Simon Gabriel Mafulul