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All Journal African Journal of Sciences and Traditional Medicine Kwaghe International Journal of Sciences and Technology
Ogugua V. N
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Agriculture, Biological Sciences & Forestry Chemical Engineering, Chemistry & Bioengineering Chemistry Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Nursing Public Health Social Sciences

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Haematological Studies of the Effects of Nauclea Latifolia Ethanolic Root Extracts in Rats Udeh Sylvester M. C; Ogugua V. N; Yakubu O. E; Parker E. J; Egba S; Anaduaka E; Ugwu O. P; Ude C. M; Iornenge T. J; Danjuma J
African Journal of Sciences and Traditional Medicine Vol 1 No 1 (2024): African Journal of Sciences and Traditional Medicine
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajstm.v1i1.3492

Abstract

Nauclea latifolia (Smith) (Family: Rubiaceae) also known as ‘Pin Cushion tree’ or ‘African Peach’ is a struggling shrub, native in tropical Africa and Asia where the use of folk medicine is preval_ent and the search for herbal cure is but common practise. Extraction of the root of Nauclea latifolia with ethanol yielded the ethanol extract. The effects of the ethanolic extract of N. latifolia on haematological parameters showed a significant elevation (p < 0.05) in packed cell volume (PCV), white blood cell count, haemoglobin concentration, red blood cell count and the white blood cell differentials compared to the control group which could be protective mechanisms against infections.
Biochemical Studies of the Effects of Nauclea Latifolia Ethanolic Root Extracts in Rats Udeh Sylvester M. C; Ogugua V. N; Ojochenemi E. Y; Parker E. J; Egba S; Anaduaka E; Ugwu O. P; Ude C. M; Iornenge T. J; Danjuma J
Kwaghe International Journal of Sciences and Technology Vol 1 No 1 (2024): Kwaghe International Journal of Sciences and Technology
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/kijst.v1i1.3564

Abstract

The plant Nauclea latifolia (Smith) (Family: Rubiaceae) also known as ‘Pin Cushion tree’ or ‘African Peach’ is a struggling shrub, native in tropical Africa and Asia where the use of folk medicine is preval_ent and the search for herbal cure is but common practice. Extraction of the root of Nauclea latifolia with ethanol yielded the ethanol extract. The acute toxicity study on the ethanol extract in mice established an intraperitoneal LD50 greater than 4000mg/kg. Thus, the ethanol extract could generally be regarded as safe. The phytochemical analysis of the Nauclea latifolia ethanol extract indicated the presence of flavonoids, saponins and reducing sugars. The result of the liver function test, alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase enzymes and the serum concentrations of conjugated and total bilirubin measured suggest mild damage of the liver hepatocytes of rats treated with ethanolic extract of Nauclea latifolia root when compared to the control. Increased serum enzyme concentrations could be associated with hepatocellular damage. The result of urea and creatinine indicate that the kidney may be damaged when compared to the control group. The extract caused a slight but non significant increase (p > 0.05) in blood glucose concentration as administration of the extract continued at days 28 and 42. The present study established that the continuous administration of the ethanol crude extract of Nauclea latifolia is lethal to the hepatocytes and kidneys.
Histopathological Studies of the Effects of Nauclea Latifolia Ethanolic Root Extracts in Rats Udeh Sylvester M. C; Ogugua V. N; Yakubu O. E; Onaga A. O; Egba S; Anaduaka E; Nghotu E. N; Ugwu O. P; Ude C. M; Iornenge T. J; Danjuma J
Kwaghe International Journal of Sciences and Technology Vol 1 No 1 (2024): Kwaghe International Journal of Sciences and Technology
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/kijst.v1i1.3620

Abstract

Nauclea latifolia (Smith) (Family: Rubiaceae) also known as ‘Pin Cushion tree’ or ‘African Peach’ is a struggling shrub, native in tropical Africa and Asia where the use of folk medicine is preval_ent and the search for herbal cure is but common practise. Extraction of the root of Nauclea latifolia with ethanol yielded the ethanol extract. The acute toxicity study on the ethanol extract in mice established an intraperitoneal LD50 greater than 4000mg/kg. Thus, the ethanol extract could be generally regarded as safe.. The histopathological sections of the liver and kidney of rats treated with ethanol extract of Nauclea latifolia showed that the extract contained some histopatotoxic compounds which might be responsible for the hepatocellular necrosis, inflammation and circulatory disturbances compared to the untreated rats. The present study established that the continuous administration of the ethanol crude extract of Nauclea latifolia is lethal to the hepatocytes and kidneys.
Co-Authors Anaduaka E Danjuma J Egba S Iornenge T. J Nghotu E. N Ojochenemi E. Y Onaga A. O Parker E. J Ude C. M Udeh Sylvester M. C Ugwu O. P Yakubu O. E