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All Journal African Journal of Sciences and Traditional Medicine Kwaghe International Journal of Sciences and Technology African Journal of Medicine, Surgery and Public Health Research
Esu Ukpai Enene
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences

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Ameliorative Effect of Ethanolic Extract of Peperomia pellucida on Anxiety in Pentylenetetrazol-Induced Epileptic Seizure in Mice Esu Ukpai Enene; Ashiya Ango; Obia Ukwula Ajah; Ante Iniobong Ating; Imoh Emmanuel Ukoh
African Journal of Sciences and Traditional Medicine Vol 2 No 2 (2025): African Journal of Sciences and Traditional Medicine
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajstm.v2i2.5815

Abstract

Although Peperomia pellucida has been traditionally used to manage central nervous system disorders, its anxiolytic properties remain insufficiently characterized. This study aimed to evaluate the anti-anxiety potential of ethanolic extract of Peperomia pellucida in a pentylenetetrazol (PTZ)-induced epileptic mouse model. Forty male Swiss albino mice (21–35 g) were randomly divided into four groups (n = 10 per group): Group A (control), Group B (PTZ 35 mg/kg, intraperitoneally), Group C (PTZ 35 mg/kg + P. pellucida 2 mg/kg, orally), and Group D (PTZ 35 mg/kg + Diazepam 0.001 mL/kg, orally). Epilepsy was induced via PTZ, confirmed by characteristic jerky movements progressing to generalized convulsions. Treatment was administered for 14 days prior to behavioral assessments. Anxiolytic activity was evaluated using the elevated plus maze and light/dark transition test. Behavioral data were analyzed using IBM SPSS Statistics version 20, with significance set at p < 0.001. Mice treated with P. pellucida exhibited significant reductions in anxiety-like behavior compared to the PTZ-only group, demonstrating increased time spent in the open arms of the elevated plus maze and in the light compartment of the light/dark box. These effects were comparable to those observed in the Diazepam-treated group. The findings suggest that ethanolic extract of Peperomia pellucida possesses notable anti-anxiety activity in PTZ-induced epileptic mice, supporting its potential as a complementary therapeutic agent for anxiety-related conditions.
Assessing the Anti-Epileptic and Anti-Nociceptive Potentials of Pepperomia pellucida in Pentylenetetrazol-Induced Epileptic Seizure in Mice Esu Ukpai Enene; Obia Ukwula Ajah; Agnes I. Odey; Alice Ashiya Ango; Samuel Mobisson
Kwaghe International Journal of Sciences and Technology Vol 2 No 2 (2025): Kwaghe International Journal of Sciences and Technology
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/kijst.v2i2.5483

Abstract

Background: Epilepsy has become one of the major public health problems in the world is characterized by seizures resulting from abnormal electrical discharges in the brain. Hence, this study to assess the anti-epileptic and antinoceptive potentials of Pepperomia pellucida in pentylenetetrazol-induced epileptic mice model. Methods: Forty (40) Swiss male albino mice weighing 21 to 35kg were randomly assigned into four groups (A to D) ten mice each and treated as follows: Group A served as the control, Group B received pentylenetetrazol 35mg/kg intraperitoneally, Group C received pentylenetetrazol 35mg/kg intraperitoneally + peperomia pellucida 2mg/kg orally, and Group D received pentylenetetrazol 35mg/kg intraperitoneally + Diazepam 0.001ml/kg orally. Pentylenetetrazol 35mg/kg intraperitoneally was used to induce epilepsy and the animals were considered epileptic after few minutes with a jerky movement of the tail and limb progressing to the entire body. All animals had access to food and water ad libitum. After administration for 14 days, epilepsy was induced and then neurobehavioral studies for nociception was assessed using the formalin test. Results: pentylenetetrazol 35mg/kg had significant epileptic seizures scores as evidenced by increased duration of seizures, frequency of jerks, onset of tonic seizures and onset of seizures and also had significant edema of the animals’ paw. Peperomia pellucida significantly ameliorated the epileptic seizure and reduced the edema of the animals’ paw induced by the pentylenetetrazol. IBM SPSS statistical software version 20, was used to analyze the data p<0.001. Conclusions: It is based on these results, we draw the conclusion that Peperomia pellucida may possess anti-epileptic and anti-nociceptive properties that resulted in the significant reduction in the epileptic seizures and edema of the animals’ paw in the Peperomia pellucida treated group.
Evaluation of the Effect of Rauwolfia vomitoria on Visuospatial and Cognitive Functions in Mice Esu Ukpai Enene; Agnes I. Odey; Imoh Ukoh; Samuel Mobisson
African Journal of Medicine, Surgery and Public Health Research Vol 2 No 2 (2025): African Journal of Medicine, Surgery and Public Health Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajmsphr.v2i2.5305

Abstract

Background: Due to the detrimental and adverse effect intense oxidative stress has on the brain resulting in cognitive function impairment. Hence, this study to evaluate the effect of Rauwolfia vomitoria on visuospatial and cognitive function in mice. Methods: Thirty (30) Swiss male albino mice weighing 19 to 35g were randomly assigned into three groups (A to C) ten mice each and treated as follows: Group A served as the control, Group B received 3-NP 20mg/kg via intraperitoneally for 5 days, Group C received 3-NP 20mg/kg intraperitoneally and Rauwolfia vomitoria 15mg/kg orally. Treatment was for 21 days and thereafter, neurobehavioral studies for visuospatial learning and memory was assayed using the Morris water maze test while cognition was evaluated using the novel object recognition test. IBM SPSS statistical software version 20, was used to analyze the data (P-value=<0.05) Results: 3-NP 20mg/kg significantly impaired cognition, as evidenced by decreased total exploration time, decreased index of habituation and decreased index of discrimination in the novel object recognition test. And also 3-NP caused impairment in visuospatial learning as evidenced by decreased retention quadrant duration, decreased annulus acquisition duration and decreased annulus reversal. Rauwolfia vomitoria treated group significantly ameliorated the visuospatial and cognitive impairments induced by 3-NP. Conclusions: It is based on these results, we draw the conclusion that R. vomitoria may possess memory enhancing property that resulted in the reversal of the visuospatial and cognitive decline in the Rauwolfia vomitoria (15mg/kg) treated group.
Co-Authors Agnes I. Odey Alice Ashiya Ango Ante Iniobong Ating Ashiya Ango Imoh Emmanuel Ukoh Imoh Ukoh Obia Ukwula Ajah Samuel Mobisson