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All Journal African Journal of Clinical Medicine and Pharmacy Research
Aasegh T. J.
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Synthesis and Characterization of Hydrogel from Gongronema latifolium for Potential Drug Delivery Amadi I. J.; Attah D. A.; Ugye T. J; Ikpatim S.; Aasegh T. J.
African Journal of Clinical Medicine and Pharmacy Research Vol 2 No 3 (2025): African Journal of Clinical Medicine and Pharmacy Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajcmpr.v2i3.7783

Abstract

This study investigates the synthesis and characterization of a plant-based hydrogel derived from Gongronema latifolium leaf extracts for potential drug delivery applications. Bioactive compounds—alkaloids, flavonoids, terpenoids, and saponins—were extracted using standard phytochemical methods. The biocompatible hydrogel was synthesized using polyvinyl alcohol (PVA) and polyethylene glycol (PEG) monomers and subsequently characterized by UV-Visible spectroscopy, Fourier Transform Infrared Spectroscopy (FTIR), Thermogravimetric Analysis (TGA), Scanning Electron Microscopy (SEM), and X-Ray Diffraction (XRD). The results confirmed successful incorporation of the plant extracts into the hydrogel matrix, forming a porous, interconnected 3D polymer network. TGA analysis indicated good thermal stability, bioactivity, and a semi-crystalline structure with high entrapment efficiency—features desirable for controlled drug delivery, water retention, and solute diffusion. FTIR spectra confirmed the presence of hydroxyl and carbonyl functional groups, suggesting strong hydrogen bonding and effective polymeric crosslinking. SEM imaging revealed a rough, heterogeneous surface with interconnected pores, while XRD analysis indicated predominantly amorphous characteristics with slight crystallinity. The findings demonstrate the successful development of a structurally stable and bioactive hydrogel with promising therapeutic and agricultural applications. The hydrogel offers a sustainable alternative to conventional petrochemical-based materials, aligning with eco-friendly innovation in drug delivery systems.
Synthesis and Characterization of Hydrogel from Gongronema latifolia for Potential Drug Delivery Amadi I. J; Attah Daniel E. B; Ugye T. J; Ikpatim S; Aasegh T. J.
African Journal of Clinical Medicine and Pharmacy Research Vol 3 No 1 (2026): African Journal of Clinical Medicine and Pharmacy Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajcmpr.v3i1.8018

Abstract

This study reports the synthesis and characterization of a plant-based hydrogel derived from Gongronema latifolium leaf extracts for potential drug delivery applications. Bioactive components, including alkaloids, flavonoids, terpenoids, and saponins, were extracted from the leaves using standard procedures, after which a biocompatible hydrogel was synthesized from poly(vinyl alcohol) (PVA) and polyethylene glycol (PEG) and characterized using UV–visible spectroscopy, Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), scanning electron microscopy (SEM), and X-ray diffraction (XRD). The results confirmed the successful incorporation of the plant extracts, revealing a porous, interconnected three-dimensional polymer matrix. TGA data showed that the hydrogel is thermally stable, bioactive, and possesses semicrystalline porous structures with high entrapment capacity, making it suitable for drug delivery, water retention, and solute diffusion. FTIR analysis confirmed the presence of hydroxyl, carbonyl, and other functional groups, indicating strong hydrogen bonding and extensive polymeric crosslinking. SEM images revealed a rough, heterogeneous surface morphology with interconnected pores, while XRD patterns indicated slight crystalline features within an overall amorphous structure. Collectively, these findings demonstrate the successful development of a structurally robust and bioactive hydrogel with promising applications in drug delivery and agriculture. The hydrogel’s properties position it as an attractive alternative to synthetic petrochemical-based materials that pose environmental risks and highlight the potential of Gongronema latifolium leaf-extract-based hydrogels for future therapeutic and drug delivery applications.
Co-Authors Amadi I. J Amadi I. J. Attah D. A. Attah Daniel E. B Ikpatim S Ikpatim S. Ugye T. J