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All Journal Malahayati International Journal of Nursing and Health Science Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
I Made Oka Adnyana
Universitas Udayana
Health Professions Nursing Public Health

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Korelasi Kualitas Tidur Buruk dengan Penurunan Fungsi Kognitif pada Lansia Panti Sosial Tresna Werdha Wana Seraya Denpasar Wildan Sifa’ul Mahsyar; I Made Oka Adnyana; Desak Ketut Indrasari Utami; Ida Ayu Sri Wijayanti
Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Vol. 6 No. 2 (2026): Juli: Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jikki.v6i2.10939

Abstract

Background: The increasing elderly population brings health challenges in the form of sleep disorders and cognitive decline. Poor sleep quality is often associated with decreased cognitive performance, but previous studies have shown inconsistent results. Objective: This study aims to determine the correlation between poor sleep quality and cognitive decline in the elderly at the Wana Seraya Social Home for the Elderly, Denpasar. Method: This study is an analytical observational study with a cross-sectional design conducted from November 2025 to January 2026. The research instrument used the Pittsburgh Sleep Quality Index to assess sleep quality and the Indonesian version of the Montreal Cognitive Assessment (MoCA-Ina) to assess cognitive function. Data were analyzed using the Spearman Rank correlation test. Results: The majority of respondents had poor sleep quality (69.7%) and impaired cognitive function (97%). The results of statistical analysis showed a weak positive correlation (r = 0.268) but the relationship was not statistically significant (p = 0.131). Conclusion: There was no significant relationship between poor sleep quality and cognitive decline in the elderly at the study site. These results indicate that sleep quality is not the sole factor contributing to the decline in cognitive function in the elderly.
HER2 positivity as a predictor of brain metastases in breast cancer: A systematic literature review Sakinah Mar'ie Sanad; I Made Oka Adnyana; I Putu Eka Widyadharma
Malahayati International Journal of Nursing and Health Science Vol. 8 No. 8 (2025): Volume 8 Number 8
Publisher : Program Studi Ilmu Keperawatan-fakultas Ilmu Kesehatan Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/minh.v8i8.1159

Abstract

Background: Breast cancer remains one of the most prevalent and lethal malignancies among women globally, which leads to the critical importance of early detection and a more comprehensive approach to breast cancer management. Purpose: To investigate HER2 positivity as a predictor of brain metastases in breast cancer. Methods: A total of 23 peer-reviewed studies published between 2015 and 2025 were analyzed, including randomized trials, retrospective cohorts, prediction model studies, and registry-based evaluations. Eligibility was guided by the PICOTS framework, and databases searched included PubMed, Scopus, MDPI, Elsevier, SagePub, and BMC Cancer. Results: The review confirms that HER2 overexpression significantly correlates with earlier brain metastasis onset, increased incidence, and distinctive treatment response profiles. HER2 status also influences survival outcomes and benefits from targeted agents such as trastuzumab, tucatinib, and pyrotinib. HER2-low expression additionally showed intermediate risk profiles, while imaging and circulating tumor cell data added prognostic value. Conclusion: HER2 positivity is a robust, independent predictor of brain metastasis in breast cancer patients. Routine integration of HER2 profiling in CNS risk assessment models may improve early detection and therapeutic precision, ultimately enhancing clinical outcomes for high-risk populations.
Co-Authors Desak Ketut Indrasari Utami I Putu Eka Widyadharma Ida Ayu Sri Wijayanti Sakinah Mar'ie Sanad Wildan Sifa’ul Mahsyar