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All Journal Eksakta : Berkala Ilmiah Bidang MIPA
Della Hashfi Anzhari
Department of Blood Bank Technology, Politeknik Bina Trada, Semarang, Indonesia
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Energy Engineering Environmental Science Materials Science & Nanotechnology Mathematics Mechanical Engineering

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Platelet-Rich Plasma (PRP) Allogenic: A Potential Challenge for Decreasing Random Blood Glucose, Uric Acid, and Cholesterol Levels in A Preliminary Pre and Post Test Study on Adult Subjects Diah Hastuti; Awal Prasetyo; Della Hashfi Anzhari; Resti Ariani; Mutia Syafira; Anna Kartika Yuli Astuti; Rina Puspita
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 27 No. 01 (2026): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol27-iss01/643

Abstract

Ideally, metabolic homeostasis is maintained through stable glucose regulation, balanced lipid metabolism, and effective uric acid clearance under conditions of minimal systemic inflammation. In real clinical conditions, aging and persistent low-grade inflammation frequently disrupt this balance, leading to hyperglycemia, dyslipidemia, and elevated uric acid levels. Current pharmacological management mainly emphasizes metabolic control and may not sufficiently address underlying tissue dysfunction or inflammatory processes. Platelet-rich plasma (PRP) is a blood-derived bioregenerative product containing growth factors with anti-inflammatory and regenerative properties, offering a potential supportive approach for metabolic regulation. Nevertheless, PRP administration has predominantly relied on invasive delivery methods. Nebulization provides a non-invasive pulmonary route that enables rapid systemic absorption, representing an alternative delivery strategy. Despite its potential advantages, clinical evidence regarding the metabolic effects of PRP delivered via nebulization remains limited, creating an urgent need for preliminary clinical evaluation. Therefore, this pre–post test study aimed to assess the effects of allogeneic PRP nebulization on random blood glucose, uric acid, and total cholesterol levels. Fourteen adult subjects received PRP nebulization for five consecutive days. The intervention resulted in a significant reduction in random blood glucose levels and mild decreasing trends in uric acid and total cholesterol without serious adverse events.
The Effect of Single and Double Dose Platelet Apheresis on Platelet Count A Thrombopoietin Levels and Percentage of Immature Platelet Fraction of Donor Post Donation Aulia Ramadhan Supit; Della Hashfi Anzhari; Saptuti Chunaeni; Rahajuningsih Dharma Setiabudy
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 27 No. 02 (2026): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol27-iss02/663

Abstract

Thrombapheresis is commonly used to obtain platelet concentrates; however, different collection doses may affect donor hematological responses. This study aimed to compare the effects of single-dose and double-dose thrombapheresis on platelet count, thrombopoietin (TPO) levels, and immature platelet fraction (IPF). A prospective comparative study with repeated measures was conducted in eight healthy donors (n = 8; 4 per group) at the Indonesian Red Cross Blood Donation Unit, Tangerang. Blood samples were collected before, immediately after, and on day 2 and day 4 post-donation. Platelet count and IPF were measured using an automated hematology analyzer, while TPO levels were assessed by ELISA. Data were analyzed using two-way ANOVA and Pearson correlation (p < 0.05). Platelet counts decreased immediately after thrombapheresis (23% in single-dose; 24% in double-dose) and gradually recovered. Significant effects of time and dose were observed (p < 0.05), but no difference between groups at day 4 (p > 0.05). TPO increased in both groups (50% vs 27%), and IPF changes were not significant (p > 0.05). A positive but non-significant correlation between TPO and IPF was found. Both procedures cause transient platelet reduction with gradual recovery. Findings should be interpreted cautiously due to the small sample size.
Co-Authors Anna Kartika Yuli Astuti Aulia Ramadhan Supit Awal Prasetyo Diah Hastuti Mutia Syafira Rahajuningsih Dharma Setiabudy Resti Ariani Rina Puspita Saptuti Chunaeni