Article Per Year (5 Year)
p-Index From 2021 - 2026
0.444
P-Index
This Author published in this journals
All Journal MEDULA Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo
Tien
Halu Oleo University
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
The Impact of the Ethyl Acetate Fraction of Bitter Melon Fruit (Momordica charantia l.) on Insulin Hormone Levels of Diabetic Rats (Rattus norvegicus) Using the Enzyme-Linked Immunosorbent Assay Method Parawansah; Tien; Amiruddin Eso; Muhammad Junaid Azis; Nuralifah
MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo Vol. 10 No. 3 (2023): Suplemen
Publisher : MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: The World Health Organization (WHO) has forecast a rise in the prevalence of diabetes mellitus from 2.8% in 2000 to 4.4% in 2030. Numerous investigations have been undertaken to identify alternate avenues for antidiabetic treatment. Momordica charantia, sometimes referred to as bitter melon, is recognized for its possession of mimic insulin components. The ethanol extracts derived from Momordica charantia have been found to exhibit favorable outcomes in the reduction of blood glucose levels and the stimulation of pancreatic beta cells for the secretion of insulin hormone. Purpose: The purpose of this research is to investigate the impact of bitter melon extract on insulin levels in rats induced with streptozotosin. Method: The present study employed various methodologies to investigate the research question. The present investigation comprised three distinct sets of tests, specifically streptozotosin-induced rats, streptozotosin-induced rats administered with an ethyl acetate fraction of Momordica charantia extract, and non-induced streptozotosin rats. The measurement of insulin levels is conducted using the enzyme-linked immunosorbent assay (ELISA) technique. If the p-value was more than 0.05, an unpaired T-test was employed for data analysis. Result: The research findings indicate that there is no statistically significant distinction in the insulin levels between streptozotosin-induced rats and streptozotosin-induced rats administered with the ethyl acetate fraction of the Momordica charantia extract group (p = 0.081). The insulin levels of streptozotosin-induced rats administered with an ethyl acetate fraction of Momordica charantia extract were found to be statistically similar to those of non-induced streptozotosin rats (p = 0.505). Conclusion: There is no discernible distinction in the insulin levels among streptozotosin-induced rats, streptozotosin-induced rats administered with an ethyl acetate fraction of Momordica charantia extract, and non-induced streptozotosin rats.
VAS Pain Analysis Before and After Genicular Nerve Block in Different Types Occupations of Knee Osteoarthritis Patients in Orthopedic Polyclinic Hati Mulia General Hospital Kendari Febriski Okta Bimantara S; Muhammad Rustam HN; Tien
MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo Vol. 11 No. 2 (2024)
Publisher : MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46496/medula.v11i2.39

Abstract

ABSTRACT Background: Knee OA patients suffer from joint pain, stiffness, instability, and swelling. This causes a decrease in the quality of life and daily activities. Knee osteoarthritis is a multifactorial disease, namely modifiable and non-modifiable factors. One of the modifiable risk factors for OA is occupation. One of the therapies for knee OA is Genicular Nerve Block (GNB). Purposes: to determine the correlation between the type of work and VAS of pain before and after genicular nerve block in knee OA patients at the Orthopedic Clinic, Hati Mulia General Hospital, Kendari. Methods: This quasi-experimental research used a one-group pretest-posttest design approach without control. This study has conducted using a questionnaire (informed consent, respondent form, and VAS sheet) from 29 OA patients before and after genicular nerve block (GNB) was performed at the orthopedic polyclinic of Hati Mulia General Hospital for the period November 2021. The dependent variable observed was VAS and the independent variable observed was the type of work. Data analysis used the Spearmen and Wilcoxon statistical test and if p <0.05, it indicated that there was a correlation between the independent and dependent variables. Results: Analysis of the correlation between occupational type and VAS pain before genicular nerve block (GNB) obtained p-value = 0.624, the correlation between occupational type and VAS pain after GNB obtained p-value = 0.716, and the influence before and after GNB on VAS pain obtained p-value = 0.000. Conclusion: There was no correlation between the occupational type and the pain VAS before and after Genicular nerve block (GNB) there was a difference before and after the Genicular nerve block (GNB) on the pain VAS. Keywords: Osteoarthritis, ocupational type, VAS, GNB
Co-Authors Amiruddin Eso Febriski Okta Bimantara S Muhammad Junaid Azis Muhammad Rustam HN Nuralifah Parawansah