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All Journal MEDULA Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo
Arimaswati
Halu Oleo University
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Anti-inflammatory Activity of Kappaphycus Alvarezii Using Protein Denaturation Inhibition Method Windy Zafa Amalia; Sulastrianah; Arimaswati
MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo Vol. 11 No. 2 (2024)
Publisher : MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46496/medula.v11i2.37

Abstract

ABSTRACT Background: Inflammation is the body's reaction to injury or tissue damage. As an NSAID, diclofenac sodium is frequently used. But since this medication has adverse effects, a substitute is required. Flavonoids found in K. alvarezii may have therapeutic uses and anti-inflammatory potential. Purpose: The goal of this research was to investigate the anti-inflammatory effect of K. alvarezii utilizing the protein denaturation inhibition method. Method: The IC50 was utilized to test anti-inflammatory effect through protein denaturation inhibition. Diclofenac sodium served as a positive control. The data were then analyzed with an independent t-test. Result: The anti-inflammatory activity test produced an IC50 of 197.94 ppm for extract K. alvarezii and 35.7 ppm for diclofenac sodium. The statistical test found a significant difference between seaweed ethanol extract K. alvarezii and sodium diclofenac (p = 0.000). Keywords: anti-inflammatory; Kappaphycus alvarezii; protein denaturation inhibition.
The Effect of Counseling on Mothers Knowledge And Attitudes About Preventing DBD In Children In The Working Area of Poasia Health Center Ryaasti Zalzabila Ramadan; Wa Ode Sitti Asfiah Udu; Arimaswati
MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo Vol. 12 No. 2 (2025): Juli
Publisher : MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo

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Abstract

ABSTRACT Background. Dengue Hemorrhagic Fever (DHF) is an infectious disease caused by a virus dengue. Poasia Health Center is one of the health centers with the most dengue fever cases. The most patiens occur at ages 4-16 years. DHF cases that occur in children can be caused a lack of knowledge and preventive attitudes carried out within the family. The aim of this research is to determine the effect of counseling on mothers' knowledge and attitudes regarding preventing dengue fever in children in the Poasia Health Center working area. Method. This research is Quasi-Eksperiment with design Without Control Groups Pretest-Posttest Design which was carried out in the Poasia Community Health Center working area. The independent variable being dengue prevention counseling while the dependent variable is the mother's knowledge and attitude. The number of samples in this study is 143 people. Data on maternal knowledge and attitudes were collect using a questionnaire and then analyze using the Wilcoxon test. Results. The dominant age was 20-30 years old with a total of 91 people with a percentage of 63.6% and the dominant last education was high school/equivalent with a total of 53 people with a percentage of 37.1%. A total of 143 respondents experienced an increase in knowledge after the counseling intervention and an increase in attitudes for 140 respondents. The results of testing knowledge and attitude data using the Wilcoxon test showed a value of p= 0.000 (p<0.05). Conclusion. There is an influence of counseling on mothers' knowledge and attitudes regarding preventing dengue fever in children in the Poasia Health Center working area. Keywords: Mother, Dengue Hemorrhagic Fever, Counseling, Knowledge, Attitude
Co-Authors Ryaasti Zalzabila Ramadan Sulastrianah Wa Ode Sitti Asfiah Udu Windy Zafa Amalia