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All Journal Indonesian Journal of Jamu
Muhammad Ryan Radix Rahardian
Department of Pharmaceutical Biology, Sekolah Tinggi Ilmu Farmasi (STIFAR) Yayasan Pharmasi Semarang, Semarang, Central Java, 50192
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology

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In Vitro and In Silico Evaluation of Pancreatic Lipase Inhibition by Avicennia marina and Bruguiera gymnorrhiza Fruit Flour Extracts Afra Chairunnisa; Muhammad Ryan Radix Rahardian; Ratih Pangestuti; Yuvianti Dwi Franyoto; Lia Kusmita
Jurnal Jamu Indonesia Vol. 11 No. 2 (2026): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i2.483

Abstract

Indonesia is rich in mangrove species, including Avicennia marina (brayo) and Bruguiera gymnorrhiza (lindur), whose fruits contain bioactive metabolites with potential anti-obesity activity. This study evaluated pancreatic lipase inhibition by brayo and lindur fruit flour extracts (raw and boiled) using in vitro and in silico approaches. Extracts were prepared by remaceration with 70% ethanol. Lipase inhibition was measured using a multimode microplate reader, while metabolites were identified by LC-HRMS and evaluated by molecular docking. Raw brayo showed the highest inhibition (84.29 ± 4.24%), followed by boiled brayo (83.01 ± 4.59%), raw lindur (75.24 ± 3.02%), and boiled lindur (73.88 ± 4.00%). Docking indicated strong binding of luteolin (−8.23 kcal/mol), 9-oxo-10(E),12(E)-octadecadienoic acid (−6.75 kcal/mol), and methyl eleostearate (−6.59 kcal/mol) to pancreatic lipase. These findings support mangrove fruit flour as a natural source of lipase inhibitors for obesity management.
Co-Authors Afra Chairunnisa Lia Kusmita Ratih Pangestuti Yuvianti Dwi Franyoto