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All Journal Journal of Health Innovation and Environmental Education Journal of Academic Biology and Biology Education
Maurizio Martin Cavani Brain
Universidad Peruana Cayetano Heredia
Humanities Biochemistry, Genetics & Molecular Biology Education Environmental Science Public Health Veterinary Other

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Clinical Skills Development and Competency Assessment Needs among Nursing Assistant Students: A Design and Development Study Lachezar Manchev; Gedamu Gebreamlak Hailu; Maurizio Martin Cavani Brain; Pichayaporn Ratt; Taisia Chertenko
Journal of Health Innovation and Environmental Education Vol. 3 No. 1 (2026): June (On Going)
Publisher : Cahaya Ilmu Cendekia Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37251/jhiee.v3i1.2916

Abstract

Purpose of the study: This study aimed to develop and validate a competency-based clinical skills development model for nursing assistant students and evaluate its effectiveness in improving clinical performance, procedural competence, and self-efficacy. Methodology: A Design and Development Research (DDR) approach with a sequential exploratory mixed-methods design was employed. Phase 1 involved qualitative needs assessment with 24 students and 6 clinical instructors to identify competency gaps. A competency-based learning model integrating structured simulation, standardized rubrics, DOPS-based formative feedback, and OSCE assessment was subsequently constructed and validated by seven experts (S-CVI = 0.92). Effectiveness was evaluated using a quasi-experimental pre-test–post-test control group design with 64. Outcomes included OSCE performance, DOPS ratings, and clinical self-efficacy. Data were analyzed using ANCOVA and effect size calculations. Main Findings: The intervention group demonstrated significantly higher post-test OSCE scores (82.6 ± 5.9 vs. 69.4 ± 6.7; p < 0.001; d = 1.95), improved DOPS ratings (4.3 ± 0.4 vs. 3.5 ± 0.5; p < 0.001), and increased self-efficacy (81.1 ± 7.5 vs. 64.3 ± 8.1; p < 0.001; d = 2.09) compared to controls. Skill retention at four weeks remained significantly higher in the intervention group (p < 0.001). Novelty/Originality of this study: Findings support structured operationalization of competency-based education in assistant-level nursing training and provide an empirically grounded framework for curriculum reform.
Molecular Docking-Based in Silico Evaluation of Leaf Compounds from Coleus blumei Against MRSA Pongpawan Sethanant; Junhong Kim; Maurizio Martin Cavani Brain
Journal of Academic Biology and Biology Education Vol. 2 No. 1 (2025): June
Publisher : Cahaya Ilmu Cendekia Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37251/jouabe.v2i1.1660

Abstract

Purpose of the study: This study aims to investigate the potential of compounds derived from medicinal plants as target protein inhibitors against methicillin-resistant Staphylococcus aureus (MRSA) using an in silico approach. Methodology: This study employed an in silico molecular docking approach to evaluate active compounds from Coleus blumei leaves against MRSA. Target proteins included MecR1, PBP2a, and oxacilloyl-acylated MecR1. Docking was performed using PyRx, PyMOL, and Discovery Studio with molecular data sourced from GC-MS, PubChem, and PDB. Main Findings: The compound Hexahydro-3H-cyclopenta[a]pentalen-3-one, 2,4a,5,6,7,8-hexahydro-4,4,7a-trimethyl-, (4aR,7R,7aS) demonstrated the highest binding affinity across all three MRSA resistance-associated target proteins (PBP2a, MecR1, and oxacillin-acylated MecR1), surpassing penicillin as the control. Molecular interaction visualizations revealed stable hydrogen bonding and hydrophobic interactions with key active site residues, particularly SER, LEU, and PHE in PBP2a. Pharmacokinetic evaluation based on Lipinski's Rule of Five indicated that top-performing compounds, including this compound and Aristolone, exhibit favorable oral drug-like properties. These findings highlight the strong potential of these natural compounds as lead candidates for the development of antibacterial agents targeting MRSA resistance mechanisms. Novelty/Originality of this study: The novelty of this study lies in the utilization of specific natural compounds as potential antimicrobial agents against antibiotic resistance proteins, which have not been widely reported before. This study provides an initial basis for the development of herbal antimicrobial drug candidates for MRSA infections.
Clinical Skills Development and Competency Assessment Needs among Nursing Assistant Students: A Design and Development Study Lachezar Manchev; Gedamu Gebreamlak Hailu; Maurizio Martin Cavani Brain; Pichayaporn Ratt; Taisia Chertenko
Journal of Health Innovation and Environmental Education Vol. 3 No. 1 (2026): June (On Going)
Publisher : Cahaya Ilmu Cendekia Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37251/jhiee.v3i1.2916

Abstract

Purpose of the study: This study aimed to develop and validate a competency-based clinical skills development model for nursing assistant students and evaluate its effectiveness in improving clinical performance, procedural competence, and self-efficacy. Methodology: A Design and Development Research (DDR) approach with a sequential exploratory mixed-methods design was employed. Phase 1 involved qualitative needs assessment with 24 students and 6 clinical instructors to identify competency gaps. A competency-based learning model integrating structured simulation, standardized rubrics, DOPS-based formative feedback, and OSCE assessment was subsequently constructed and validated by seven experts (S-CVI = 0.92). Effectiveness was evaluated using a quasi-experimental pre-test–post-test control group design with 64. Outcomes included OSCE performance, DOPS ratings, and clinical self-efficacy. Data were analyzed using ANCOVA and effect size calculations. Main Findings: The intervention group demonstrated significantly higher post-test OSCE scores (82.6 ± 5.9 vs. 69.4 ± 6.7; p < 0.001; d = 1.95), improved DOPS ratings (4.3 ± 0.4 vs. 3.5 ± 0.5; p < 0.001), and increased self-efficacy (81.1 ± 7.5 vs. 64.3 ± 8.1; p < 0.001; d = 2.09) compared to controls. Skill retention at four weeks remained significantly higher in the intervention group (p < 0.001). Novelty/Originality of this study: Findings support structured operationalization of competency-based education in assistant-level nursing training and provide an empirically grounded framework for curriculum reform.
Molecular Docking-Based in Silico Evaluation of Leaf Compounds from Coleus blumei Against MRSA Pongpawan Sethanant; Junhong Kim; Maurizio Martin Cavani Brain
Journal of Academic Biology and Biology Education Vol. 2 No. 1 (2025): June
Publisher : Cahaya Ilmu Cendekia Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37251/jouabe.v2i1.1660

Abstract

Purpose of the study: This study aims to investigate the potential of compounds derived from medicinal plants as target protein inhibitors against methicillin-resistant Staphylococcus aureus (MRSA) using an in silico approach. Methodology: This study employed an in silico molecular docking approach to evaluate active compounds from Coleus blumei leaves against MRSA. Target proteins included MecR1, PBP2a, and oxacilloyl-acylated MecR1. Docking was performed using PyRx, PyMOL, and Discovery Studio with molecular data sourced from GC-MS, PubChem, and PDB. Main Findings: The compound Hexahydro-3H-cyclopenta[a]pentalen-3-one, 2,4a,5,6,7,8-hexahydro-4,4,7a-trimethyl-, (4aR,7R,7aS) demonstrated the highest binding affinity across all three MRSA resistance-associated target proteins (PBP2a, MecR1, and oxacillin-acylated MecR1), surpassing penicillin as the control. Molecular interaction visualizations revealed stable hydrogen bonding and hydrophobic interactions with key active site residues, particularly SER, LEU, and PHE in PBP2a. Pharmacokinetic evaluation based on Lipinski's Rule of Five indicated that top-performing compounds, including this compound and Aristolone, exhibit favorable oral drug-like properties. These findings highlight the strong potential of these natural compounds as lead candidates for the development of antibacterial agents targeting MRSA resistance mechanisms. Novelty/Originality of this study: The novelty of this study lies in the utilization of specific natural compounds as potential antimicrobial agents against antibiotic resistance proteins, which have not been widely reported before. This study provides an initial basis for the development of herbal antimicrobial drug candidates for MRSA infections.
Co-Authors Gedamu Gebreamlak Hailu Junhong Kim Lachezar Manchev Pichayaporn Ratt Pongpawan Sethanant Taisia Chertenko