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All Journal Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Jurnal Health Sains
Arina Shafia
Universitas Islam Sultan Agung, Semarang, Indonesia
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Herbal-Based Topical Gel of Impatiens balsamina L. Enhances Macrophage Infiltration in Traumatic Oral Mucosal Ulcer Repair Arina Shafia; Shalli Herliana Rahmawati; Isa Anshori Muchaeroni
Jurnal Health Sains Vol. 7 No. 3 (2026): Journal Health Sains
Publisher : Syntax Corporation Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/jhs.v7i3.2820

Abstract

Traumatic oral mucosal ulcers are common lesions that require effective inflammatory regulation for optimal healing, in which macrophages play a crucial role. Long-term use of topical corticosteroids is associated with adverse effects, encouraging the exploration of safer herbal-based alternatives. Impatiens balsamina L. has demonstrated anti-inflammatory and wound-healing properties; however, evidence regarding its effect on macrophage responses in traumatic oral ulcers remains limited. This research aimed to evaluate the effect of topical Impatiens balsamina L. extract gel on macrophage cell counts during the healing of traumatic oral mucosal ulcers. An in vivo experimental study with a post-test only control group design was conducted using 27 male Wistar rats. Traumatic ulcers were induced on the inferior labial vestibular mucosa and treated topically for three days with either 15% extract gel, 10% extract gel, or gel base (n= 9 per group). Macrophage counts were assessed histologically using Hematoxylin and Eosin staining. Data were analyzed using Welch’s one-way ANOVA followed by the Games–Howell post hoc test. Mean macrophage counts were highest in the 15% extract gel group (111.78 ±15.68), followed by the 10% group (45.00 ±10.56) and the control group (22.22±3.35). Significant differences were observed among all groups (P<0.001). Topical Impatiens balsamina L. extract gel significantly increased macrophage presence during traumatic oral ulcer healing, with the 15% concentration showing superior effectiveness. These findings confirm that Impatiens balsamina L. extract gel accelerates the inflammatory phase of wound healing by enhancing macrophage recruitment, supporting its potential as a natural alternative for oral ulcer management.
Bay Leaf (Syzygium Polyanthum) Extract Effect on IL-10 and IL-6 Gene Expression in Traumatic Ulcer Arina Shafia; Setyo Trisnadi; Agung Putra
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 17 No 2 (2023): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jpm.v17i2.6914

Abstract

The aims of this research is to prove the effect of bay leaf extract gel on IL-10 and IL-6 gene expression in traumatic ulcers. The research method using In vivo experimental study with a randomized posttest-only control group design. The total sample was 24 male Wistar rats, divided into four groups. Group K1 (given base gel), group K2 (given Kenalog in Orabase), group K3 (10% bay leaf extract gel), and group K4 (15% bay leaf extract gel) were given treatment for 5 days. IL-6 and IL-10 levels were tested using the One-Way Anova test, followed by the Tamhane Post Hoc test. This study revealed that there was a difference in IL-6 levels in the K4 group compared to the K1 group sig. (p = 0.007) and a significant difference in IL-10 levels in the K4 group compared to the K1 group. (p = 0.003) after being given topical treatment with bay leaf extract gel. The conclusion of this research is treatment with 15% bay leaf gel extract (Syzygium polyanthum) was proven to significantly increase IL-10 gene expression and decrease IL-6 gene expression in Wistar rats model of traumatic ulcers.
Co-Authors Agung Putra Isa Anshori Muchaeroni Setyo Trisnadi Shalli Herliana Rahmawati