Sri Yolandari
Polytechnic Baubau. Jl. Lakarambau, Lipu, Kec. Betoambari, Kota Bau-Bau, Sulawesi Tenggara 93724, Indonesia

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Formulation of Dragon Fruit Skin Nail Polish Cosmetic Preparations (Hylocereus Polyrhizus) Dinasti; Sri Yolandari; Sitti Alfyanita Ilham
Journal of Health Science and Pharmacy Vol. 2 No. 3 (2025): September - December
Publisher : Yayasan Cipta Anak Bangsa (YCAB) Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36685/jhsp.v2i3.1550

Abstract

Background: Dragon fruit (Hylocereus polyrhizus) is widely recognized for its nutritional value and health benefits. However, its peel is often discarded as waste, despite containing high levels of anthocyanins. These natural pigments are responsible for the red coloration of dragon fruit and have considerable potential as safe, environmentally friendly alternatives to synthetic dyes, particularly in cosmetic applications. Objectives: This study aims to evaluate the feasibility of utilizing dragon fruit peel extract as a natural dye in nail polish formulations and to assess the physical characteristics of the resulting cosmetic products. Methods: An experimental laboratory-based study was conducted by formulating nail polish using dragon fruit peel extract at three different concentrations: 8% (F1), 9% (F2), and 10% (F3). The formulated products were evaluated through organoleptic testing to assess physical appearance attributes, including color, form, and aroma. Panelist preferences were recorded to determine the most acceptable formulation. Results: The findings demonstrate that dragon fruit peel extract can be successfully used as a natural coloring agent in nail polish formulations. Among the three formulations, F3 (10% extract concentration) was identified as the most preferred, with 8 out of 10 panelists selecting it as the best formulation. This formulation exhibited the most attractive color intensity and the most favorable physical characteristics. Conclusion: Dragon fruit peel extract shows strong potential as a natural dye in cosmetic products, particularly nail polish. The use of a 10% extract concentration produced the most acceptable formulation, supporting the utilization of agricultural waste as a sustainable and safe alternative to synthetic cosmetic dyes.  
Effectiveness Test of Soursop Leaf Ethanol Extract (Annona muricata L) as a Healer of Incision Wounds on Mice (Mus musculus) Skin Novianti Cahyani Junadi; Sri Yolandari; Suparman Supardi
Journal of Health Science and Pharmacy Vol. 3 No. 1 (2026): January - April
Publisher : Yayasan Cipta Anak Bangsa (YCAB) Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36685/jhsp.v3i1.1583

Abstract

Background: Annona muricata (soursop) is a traditional medicinal plant widely used for wound treatment. Incision wounds are tissue injuries caused by sharp objects and may vary in severity from mild to severe. The wound healing process involves inflammatory, proliferative, and maturation phases, which can be influenced by bioactive compounds derived from natural products. Objectives: This study aimed to determine the effectiveness of ethanol extract of soursop leaves (Annona muricata L.) in accelerating the healing of incision wounds in Mus musculus. Methods: The extract was prepared using a maceration method of dried soursop leaf simplicia with 96% ethanol. A total of 15 white mice (Mus musculus) were divided into five treatment groups: (1) negative control (distilled water), (2) positive control (10% povidone iodine), (3) extract dose of 0.1 g, (4) extract dose of 0.2 g, and (5) extract dose of 0.3 g. An incision wound was made on the dorsal area of each mouse. Treatments were administered once daily for 14 days. Data were analyzed using one-way ANOVA followed by the Post Hoc LSD test to determine significant differences between groups. Results: The findings indicated that the ethanol extract of soursop leaves accelerated incision wound healing in mice, with the 0.3 g dose showing the highest effectiveness. Statistical analysis using one-way ANOVA revealed a significant difference among treatment groups (p < 0.05; p = 0.000). Further analysis using the Post Hoc LSD test confirmed significant mean differences between groups. Conclusion: The ethanol extract of soursop leaves (Annona muricata L.) is effective in accelerating incision wound healing in Mus musculus, with the 0.3 g dose demonstrating the most optimal effect. Keywords: Annona muricata L.; incision wounds; Mus musculus; ethanol extract; wound healing