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All Journal Chimica et Natura Acta
Elbagir, Sahar
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Environmental Science Materials Science & Nanotechnology

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Evaluation of Thrombotic Markers in Diabetic Septic Foot: A Study of Coagulation and Hematological Parameters in Khartoum State ALhussan, Anwar S.; Elbagir, Sahar; Alsawmhi, Sarah O.; Pyar, Hassn
Chimica et Natura Acta Vol 14, No 1 (2026)
Publisher : Departemen Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/cna.v14.n1.67779

Abstract

Diabetes mellitus is a globally prevalent chronic disease. It is characterized by a metabolic dysregulation in insulin secretion, resulting in persistent hyperglycemia. Uncontrolled HbA1c levels may lead to various complications, including diabetic Septic foot (DSF), which in severe cases can progress to lower limb amputation. Therefore, this study aimed to evaluate coagulation profiles and hematological parameters as potential thrombotic and inflammatory markers associated with diabetic foot infections. Preventive measures, patient education, and proper diabetic foot care remain the cornerstone strategies for reducing the risk and progression of such complications. The Total of 120 participants were divided into three groups by 40 patients, diabetic septic foot, without foot complications and healthy individuals (control). Coagulation and hematological parameters were assessed. Our results PT, INR, MCV, MCH, and PDW were significantly elevated in the DSF group with control group. Males were more affected than females. A moderate positive correlation was observed between HbA1c and both RBC count and PDW. Patients with diabetic septic foot exhibit significantly higher coagulation and hematological markers, particularly PT, INR, MCV, MCH, and PDW. These markers, along with HbA1c levels, may serve as potential indicators of thrombotic risk in DSF patients, especially among males.
Co-Authors Alhussan, Anwar S. Alsawmhi, Sarah O. Pyar, Hassn