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Correlation of Pregnant Women’s Knowledge of Purine Intake with Uric Acid Levels Gusti Ayu Dhanu Wantari Dewi; Ni Luh Gede Puspita Yanti; Lia Cahya Sari
Jurnal Kesehatan Cendikia Jenius Vol. 3 No. 2 (2026): April 2026
Publisher : CV. CENDIKIA JENIUS INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70920/jenius.v3i2.389

Abstract

Backgroud: Uric acid is the final product of purine metabolism, and one of the factors contributing to elevated uric acid levels is excessive purine consumption. High purine intake can increase the production of uric acid in the body. The prevalence of elevated uric acid levels in pregnant women is still common and, in advanced clinical conditions, may lead to preeclampsia. This may occur because during the second and third trimesters of pregnancy there is a decrease in glomerular filtration rate due to changes in renal function. Objective: To determine the relationship between the level of knowledge of pregnant women regarding purine intake and uric acid levels at UPTD Puskesmas III North Denpasar. Methods: This study was an analytical observational study with a cross-sectional approach. The sample consisted of 56 pregnant women in the second and third trimesters selected using accidental sampling technique. Data on the level of knowledge regarding purine intake were obtained through a questionnaire, while uric acid levels were measured using capillary blood examination with the Point of Care Testing (POCT) method. Results: The results showed that 62.5% of pregnant women had good knowledge and 71% had normal uric acid levels. The Spearman Rank correlation test showed a significance value of p = 0.000 and a correlation coefficient of r = 0.915. Conclusion : There is a significant relationship between pregnant women's knowledge about purine intake and uric acid levels, and it shows a very strong positive direction. Pregnant women are advised to be selective in choosing the foods they consume to prevent an increase in uric acid levels during pregnancy.
The Relationship Between APTT Values and LDL Levels in Heart Disease Patients with a History of Hypercholesterolemia Anak Agung Istri Ulandari; I Gst Pt Agus Ferry Sutrisna Putra; Lia Cahya Sari
Jurnal Kesehatan Cendikia Jenius Vol. 3 No. 2 (2026): April 2026
Publisher : CV. CENDIKIA JENIUS INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70920/jenius.v3i2.393

Abstract

Introduction: Heart disease with a history of hypercholesterolemia is associated with the atherosclerotic process, which may affect coagulation mechanisms, making the assessment of LDL and APTT important to analyze. Objective: This study aimed to determine the relationship between Activated Partial Thromboplastin Time (APTT) and Low-Density Lipoprotein (LDL) levels in heart disease patients with a history of hypercholesterolemia. Methods: The study employed an analytical observational cross-sectional design with 40 samples selected through consecutive sampling, conducted at the Laboratory Installation of RSUD Bangli from November 1 to December 31, 2025. Data were obtained from 8–12-hour fasting blood samples; LDL levels were analyzed using the BA 200 analyzer, while APTT was measured using the STart Max Stago instrument. Data were analyzed using Spearman’s Rank correlation test. Results: The results showed that 50% of respondents had normal APTT values and 50% had prolonged APTT, while LDL levels were predominantly in the normal category (75%), followed by the high category (25%). Spearman’s test yielded p=0.759 and r=−0.050. Conclusion: There was no significant relationship between LDL and APTT, indicating that LDL levels are not directly associated with changes in APTT. Further studies are recommended to evaluate other factors that may influence coagulation.