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La Eddy
Department of Biology, Faculty of Science and Technology, Pattimura University, Ambon – Indonesia
Biochemistry, Genetics & Molecular Biology Materials Science & Nanotechnology Medicine & Pharmacology

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Expresion of Tumor Necrosis Factor Alfa (TNF-α) in The Pancreas of Diabetic Mice (Mus musculus) Following Adminstration of Catharantus roseus Extract Nunun Ainun Putri Sari Banun Kaliky; Mechiavel Moniharapon; La Eddy
Biofaal Journal Vol 6 No 1 (2025): Biofaal Journal
Publisher : Pattimura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/biofaal.v6i1pp10-19

Abstract

Catharanthus roseus is a plant that contains compounds such as alkaloids, flavonoids, saponins, and carotenoids, which act as antioxidants. This study aimed to investigate the effect of Catharanthus roseus extract on the reduction of TNF-α expression in the pancreas of diabetic mice (Mus musculus). In this study, mice with an average body weight of 30 g were induced with streptozotocin (0.1 ml/BB) to induce diabetes mellitus. Subsequently, the diabetic mice were administered Catharanthus roseus extract, using methanol and petroleum benzene solvents at a concentration of 5%, with a dose volume of 1.5 ml/BB, for 14 days. On the final day, the mice were sacrificed, and the pancreas organs were collected, followed by histological preparation using immunohistochemistry methods. The results indicated that administration of Catharanthus roseus extract with methanol and petroleum benzene solvents reduced TNF-α expression. The Catharanthus roseus extract with methanol solvent was more effective in lowering TNF-α expression.
Screening of Antioxindant Activity of Fruit Peel and Stem Bark Extracts od Garcinis mangostana L Using the 2,2-Diphenyl-1-Picrylhydrazyl (DPPH) Method La Eddy; Nunun Ainun Putri Sari Banun Kaliky
Biofaal Journal Vol 7 No 1 (2026): Biofaal Journal
Publisher : Pattimura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/biofaal.v7i1pp49-58

Abstract

Mangosteen stem bark and rind are known to contain various bioactive compounds such as xanthones, flavonoids, and polyphenols, which can function as antioxidants. To measure the level of antioxidant ability of stem bark and mangosteen fruit peel extracts, one method that is often used is the 2,2-Diphenyl-1-Picrylhydrazyl (DPPH) method. The purpose of this study was to determine the antioxidant activity of stem bark and fruit peel extracts of Garcinia mangostana L using the 2,2- Diphenyl-1-Picrylhydrazyl (DPPH) method. Samples of stem bark and fruit peel were extracted by maceration method after that followed by antioxidant activity testing with DPPH method. The results showed that the stem bark extract of G. mangostana L. had an LC50 value of 42,95 ppm, while the fruit peel extract showed a lower LC50 value of 12,13 ppm, indicating that both had very strong antioxidant activity. The content of bioactive compounds such as phenolics, flavonoids, and xanthones is the main cause of the high antioxidant activity, making G. mangostana L. stem bark and fruit peel extracts potential therapeutic agents in the prevention and treatment of oxidative stress-related diseases.
Co-Authors Mechiavel Moniharapon Nunun Ainun Putri Sari Banun Kaliky Nunun Ainun Putri Sari Banun Kaliky