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All Journal PharmaCine: Journal of Pharmacy, Medical and Health Science
Indah Laily Hilmi
Program Studi Sarjana Farmasi, Fakultas Ilmu Kesehatan, Universitas Singaperbangsa Karawang
Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Veterinary

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Analisis Interaksi Senyawa Sinularin dan Turunannya terhadap Reseptor pada Kanker Payudara dengan Metode Penambatan Molekul: Analysis of the Interaction of Sinularin Compounds and Their Derivatives with Receptors in Breast Cancer by Molecular Docking Method Bismar Al Bara; Indah Laily Hilmi; Hadi Sudarjat
PharmaCine : Journal of Pharmacy, Medical and Health Science Vol. 5 No. 2 (2024): PharmaCine: Journal of Pharmacy, Medical and Health Science
Publisher : Bachelor of Pharmacy Study Program, Faculty of Health Sciences, Universitas Singaperbangsa Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35706/pc.v5i2.12945

Abstract

Over the past three decades, there have been thousands of women undergoing treatment with tamoxifen. But there is a decrease or even no response to the breast cancer chemotherapy treatment. This phenomenon can occur due to resistance. sinularin has potential as a cancer drug.This study aims to evaluate the interaction of sinularin compounds and its derivatives with breast cancer receptors such as estrogen receptor alpha with PDB code: 5W9C, progesterone receptor with PDB code: 1A28, and human epidermal growth factor receptor 2 using proteins with PDB code: 3PP0 using molecular docking methods to determine anticancer potential.This research method is in-silico research. The research was conducted by screening test compounds such as prediction of compound potential using PASS Online Server, prediction of physicochemical properties using SwissADME, and prediction of compound toxicity using ProTox 3.0. Then validation of the method using AutoDock Vina, Next molecular docking using AutoDock Vina, and visualization of molecular docking results using Biovia Discovery Studio Visualizer. The results showed that sinularin compounds and their derivatives showed anticancer potential through the PASS test, low toxicity, and compliance with the Lipinski Rule of Five. Method validation showed RMSD values ​​below 2.0 Å. In molecular docking, sinularin showed a binding affinity value with a value of -8.027 kcal/mol which was better than tamoxifen with a value of -7.61 kcal/mol, although still below the native ligand of estrogen receptor alpha with a value of -8.815 kcal/mol. Sinularin and its derivatives have potential as anticancer agents through interaction with ERα and HER-2. Keywords: Breast Cancer; Sinularin; Molecular Docking.
Hubungan Tingkat Pengetahuan Swamedikasi Penyakit Ringan dengan Pengelolaan Limbah Obat di salah satu Pesantren di Karawang: The Relationship Between Knowledge of Self-Medication for Minor Illnesses and Drug Waste Management at an Islamic Boarding School in Karawang Iqbal Ramdhani Asa’af; Indah Laily Hilmi; Munir Alinu Mulki
PharmaCine : Journal of Pharmacy, Medical and Health Science Vol. 6 No. 1 (2025): PharmaCine: Journal of Pharmacy, Medical and Health Science
Publisher : Bachelor of Pharmacy Study Program, Faculty of Health Sciences, Universitas Singaperbangsa Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35706/pc.v6i1.13134

Abstract

Self-medication or self-treatment is an attempt by a person to treat themselves by recognizing the symptoms or illnesses they are experiencing and choosing their own medicine. However, in reality, self-medication is not accompanied by good drug waste management. So this study aims to measure students' knowledge about self-medication and drug waste management at Insan Harapan Islamic Boarding School and analyze the relationship between students' self-medication knowledge and drug waste management. The approach used in this study is the Cross-Sectional method. The study population consisted of all high school students at Insan Harapan Islamic Boarding School in Karawang, with a sample of 187 students selected using non-probability sampling. Data were analyzed using the spearman rank test. The results showed that 60% of respondents had a high level of knowledge about self-medication for minor illnesses, while 71% demonstrated good practices in drug waste management. This study also found a significant relationship between students' knowledge of self-medication for minor illnesses and their practices in drug waste management. The correlation test shows a significance p-value test is 0.01, which is less than 0.05, so it can be concluded that there is a relationship between the level of knowledge of self-medication for minor illnesses and the management of drug waste at the Insan Harapan Karawang Islamic Boarding School. However, this relationship is low with a coefficient correlation value of 0.25. These findings highlight the importance of enhancing health education on self-medication and drug waste management, as well as developing policies to regulate drug waste management to prevent adverse environmental impacts. Keywords: Self-medication; Knowledge; Waste; Medicine.
Co-Authors Bismar Al Bara Iqbal Ramdhani Asa’af Munir Alinu Mulki Sudarjat, Hadi