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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Molecular and Cellular Biomedical Sciences (MCBS)
Joko Wahyu wibowo
Department of Nutrition, Faculty of Medicine, Universitas Islam Sultan Agung, Semarang
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience

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Community-based zinc supplementation for linear growth recovery in stunted under-five children in Indonesia Heny Yuniarti; Joko Wahyu wibowo; Shofi Khofsoftun Purjaningsih
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 16, No 1 (2025): June 2025
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/sainsmed.v16i1.47046

Abstract

Stunting remains a significant nutritional challenge in Indonesia and across Southeast Asia, with zinc deficiency identified as a contributing factor to impaired linear growth in early childhood. Zinc is critical for growth hormone synthesis, bone development, and immune regulation. Despite existing intervention programs, stunting prevalence in Indonesia remained at 19.8% in 2024. This study evaluated the effect of zinc supplementation on the linear growth of stunted children aged 0–5 years attending Bangetayu and Genuk Public Health Centres in Semarang. Employing an observational analytic design with a one-group pretest-posttest approach, 42 stunted toddlers received a daily oral dose of 20 mg zinc sulfate syrup for two months. Anthropometric measurements were recorded before and after the intervention, with paired T-tests applied to normally distributed data and Wilcoxon signed-rank tests to non-normal data. After two months of supplementation, 86% of the participants demonstrated improvements in both height and weight. The mean height increased from 79.9 cm to 81.0 cm (p < 0.001), while the mean weight increased from 9.28 kg to 9.74 kg (p < 0.001). These findings indicate that zinc supplementation significantly enhances linear growth among stunted toddlers. Consequently, integrating zinc supplementation into national nutrition intervention strategies could be pivotal in reducing early childhood stunting.
Synergistic Effect of Propolis Extract and Vitamin E on TNF-α Reduction in High Fat Diet–Induced Rats Novitasari Anggraini; Joko Wahyu Wibowo; Hadi Sarosa
Molecular and Cellular Biomedical Sciences Vol 10, No 2 (2026)
Publisher : Cell and BioPharmaceutical Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21705/mcbs.v10i2.779

Abstract

Background: High-fat diet (HFD) can lead to a low-grade inflammatory state in the body called meta-inflammation. Propolis and Vitamin E are proven to act as antiinflamatories by inhibiting the NF-Kβ pathway, inhibiting lipid peroxidation, and scavenging free radicals. TNF-α is a biomarker for the analysis of acute pro-inflammatory cytokines. This study aimed to determine the effect of propolis extract and vitamin E on TNF-α responses in HFD-induced rats.Materials and methods: A randomized controlled trial with post-test only with control group design. Thirty Wistar rats were acclimatized for 7 days, prior to randomization into five groups that are C group (standard diet), T1 group (HFD 2 mL of quail eggs/day),  T2 group (HFD + vitamin E 12mg /200 g of rat BW/day),  T3 group (HFD + propolis extract 36 mg /200 g of rat BW/day), and T4 group (HFD + vitamin E 6 mg/200 g of rat BW/day + propolis extract 18 mg/200 g of rat BW/day).  All intervention were administered orally for 14 days. TNF-α were measured from periorbital blood sample on day 15th using ELISA.Results: TNF-α highest levels was found in HFD group (T1) on 90.53±10.48 ng/L and the lowest was found in propolis group (T3) on 68.21±3.97 ng/L. Combination group (T4) has TNF-α levels on 68.46±15.39ng/L. One way ANOVA showed significant differentiation p<0.05.Conclusion: Propolis extract and vitamin E significantly reduced TNF-α levels on HFD induced rats, either in single form or in combination. This shows their rule as anti-inflammatory agent. Keywords: high fat diet, propolis extracts, TNF-α ,vitamin E
Co-Authors Hadi Sarosa Heny Yuniarti Novitasari Anggraini Shofi Khofsoftun Purjaningsih