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Bintari Tri Sukoharjanti
Universitas Muhammadiyah Kudus, Kudus, Indonesia
Health Professions

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Effectiveness of Antibiotic Use in Pediatric Diarrheal Patients Inpatient Bhina Bhakti Husada Rembang Hospital Eko Retnowati; Puput Syah Inta Purnama; Bintari Tri Sukoharjanti; Nura Ali Dahbul
Advances in Healthcare Research Vol. 4 No. 1 (2026)
Publisher : Yayasan Pendidikan Bukhari Dwi Muslim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60079/ahr.v4i1.729

Abstract

Purpose: This study aimed to analyze the characteristics of pediatric inpatients with diarrhea and to evaluate the relationship between the type of antibiotics used and therapeutic effectiveness at Bhina Bhakti Husada Rembang Hospital. It was hypothesized that differences in antibiotic type might influence treatment effectiveness, although other clinical factors could also contribute. Research Method: This study used a descriptive-analytic design with a retrospective approach based on medical records of 106 pediatric inpatients diagnosed with diarrhea during June–December 2025. Data included age, sex, antibiotic type, length of hospital stay, and diarrhea frequency before and after therapy. Therapeutic effectiveness was assessed based on length of hospitalization, with ≤3 days categorized as effective and >3 days as ineffective, supported by improvement in diarrhea frequency. Data were analyzed descriptively and bivariately. Results and Discussion: Most patients were aged 1–5 years (54.7%) and male (67.9%). Nitroimidazole was the most frequently used antibiotic (53.8%), followed by third-generation cephalosporins (34.0%). Overall, 57.5% of patients were categorized as effective and 42.5% as ineffective. No significant relationship was found between antibiotic type and therapeutic effectiveness. Implications: These findings suggest that treatment success in pediatric diarrhea is multifactorial and not solely determined by antibiotic class. Further research should include disease severity, hydration status, nutritional condition, and local resistance patterns.
Formulation and Physical Quality Testing of Cleansing Balm from Centella Asiatica (L.) URB. Extract with Castor Oil (Ricinus Communis L.) as a Makeup Remover Sevty Ardhia Pramesty; Hasriyani Hasriyani; Bintari Tri Sukoharjanti
Advances in Healthcare Research Vol. 3 No. 2 (2025)
Publisher : Yayasan Pendidikan Bukhari Dwi Muslim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60079/ahr.v3i2.597

Abstract

Purpose: This study aimed to formulate and evaluate the physical quality of cleansing balm containing 3% Centella asiatica (L.). Urb. Extract with castor oil (Ricinus communis L.) at varying concentrations (30%, 35%, and 40%) to determine the optimal formulation as an effective and safe makeup remover. Research Method: An experimental laboratory design was conducted at the Cendekia Utama Kudus Institute of Health Technology. The Centella asiatica extract was obtained from UPT Lab Herbal Materia Medica Batu, East Java. Physical quality tests included organoleptic, homogeneity, pH, spreadability, adhesion, melting point, cleansing ability, and skin irritation tests. Data analysis was performed using SPSS, including tests for normality, homogeneity, One-Way ANOVA, and post hoc Tukey tests. Six female volunteers aged 18–30 participated in the irritation test. Results and Discussion: All formulations met physical quality standards. Formula 1 (3% Centella asiatica + 30% castor oil) demonstrated optimal results, exhibiting the best cleansing ability, easy rinsing, an ideal pH (5.61), good spreadability (4.91 cm), the highest adhesion (13.43 s), and no irritation in any of the volunteers and increasing the castor oil content above 35% reduced cleansing effectiveness, despite improving spreadability. No formulation caused erythema or edema during the 72-hour observation. Implications: The findings support the potential use of Centella asiatica and castor oil in natural, safe, and effective cleansing balm formulations. Future research should assess long-term stability, consumer acceptance, and potential scalability for commercial production.
Co-Authors Eko Retnowati Hasriyani Hasriyani Nura Ali Dahbul Puput Syah Inta Purnama Sevty Ardhia Pramesty