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Lourdes Fatima S. David
Mabalacat City College
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Hypolipidemic and Adipose-reducing Effects of Ethanolic Extract of Ziziphus Talanai (Blanco) Merr. in Monosodium Glutamate-Induced Obese Female Albino Rats Maria Anabelle A. Samson; Lourdes Fatima S. David; Glen S. Nolasco; John Dave Dicuangco; Marilyn S. Arcilla
Journal of Healthcare and Biomedical Science Vol. 3 No. 1 (2024): December Issue
Publisher : Research Synergy Foundation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31098/jhbs.v3i1.2738

Abstract

Obesity is a global health-related risk factor associated with metabolic disorders characterized by excessive fat accumulation and high lipid serum profile. One major factor contributing to obesity is the chronic consumption of monosodium glutamate (MSG). Generally, this study aimed to evaluate the hypolipidemic and anti-adipogenic effects of Ziziphus talanai ethanolic leaf extract (ZTELE) in MSG-induced obesity in female albino rats. A total of twelve (12) female albino rats were used in the study and divided into four treatment groups: T (distilled water), T+ (simvastatin), T1 (400 mg/kg ZTELE), and T2 (800 mg/kg ZTELE). Before treatment, rats were fed a high-fat diet and MSG for 1 month to induce obesity. Significant reductions in body weight, intrascapular and visceral fats, and selected lipid serum profiles (total cholesterol, high-density lipoproteins, low-density lipoproteins) were observed in the ZTELE-treated groups (T1 and T2), with comparable results to those of simvastatin-treated (T+). Phytochemicals, such as flavonoids, saponins, and tannins, influence metabolic pathways by their antioxidative potential, inhibition of lipid synthesis, and regulation of fat cell differentiation. In conclusion, ZTELE is a promising natural therapeutic agent for managing obesity by regulating fat accumulation and lipid metabolism.
Protective Effects of Premna serratifolia L. Leaf Extract Against Gentamicin-Induced Nephrotoxicity in ICR Mice Josel D. Cruz; Glen S. Nolasco; John Dave A. Dicuangco; Lourdes Fatima S. David
Journal of Healthcare and Biomedical Science Vol. 3 No. 1 (2024): December Issue
Publisher : Research Synergy Foundation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31098/jhbs.v3i1.2752

Abstract

Many therapeutic drugs, including aminoglycosides, are known to cause nephrotoxicity and impair kidney function. Gentamicin is a type of aminoglycoside commonly used to treat infection caused by gram-negative bacteria, but it can induce nephrotoxicity by accumulation in the proximal convoluted tubules, resulting in stress, degeneration, and injury to the kidney. Although traditional treatments are limited, natural products, such as in Premna serratifolia, have potential for ameliorative bioactivities. This study examined the nephroprotective effects of P. serratifolia ethanolic leaf extract (PSELE) against gentamicin-induced nephrotoxicity in male ICR mice. Twelve male ICR mice were divided into four groups: normal (T0), negative (T-), 0.3 ml/20 g b.w. PSELE-treated (T1), and 0.5 ml/20 g b.w. PSELE-treated (T2). The kidneys were then extracted, weighed, and subjected to histopathological examination. Results showed that PSELE counteracts gentamicin-induced nephrotoxicity by mitigating its effect on weight and kidney tissue alterations in PSELE-treated mice (T1 and T2), with comparable results to normal (T0). The protective effects of the extract were attributed to the phytochemicals that mitigated the oxidative stress of gentamicin. In conclusion, PSELE is a potential therapeutic agent for nephrotoxicity mitigation.
Co-Authors Glen S. Nolasco John Dave A. Dicuangco John Dave Dicuangco Josel D. Cruz Maria Anabelle A. Samson Marilyn S. Arcilla