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Widdhi Bodhi
Department of Chemistry, Faculty of Medicine, Sam Ratulangi University, Manado, Indonesia
Agriculture, Biological Sciences & Forestry Chemical Engineering, Chemistry & Bioengineering Engineering Medicine & Pharmacology Physics

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Antioxidant Potential of Yellow Chrysanthemum (Chrysanthemum indicum) Leaves: In Vitro Analysis Using DPPH and FRAP Techniques Gabriella Therezia Ley Ley; Billy Johnson Kepel; Fatimawali Fatimawali; Aaltje Ellen Manampiring; Fona Dwiana Hermina Budiarso; Widdhi Bodhi
Grimsa Journal of Science Engineering and Technology Vol. 3 No. 2 (2025): October 2025
Publisher : Graha Primera Saintifika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61975/gjset.v3i2.68

Abstract

The shift from infectious diseases to non-communicable diseases (NCDs), driven by aging and unhealthy lifestyles, has led to an increase in degenerative diseases. The World Health Organization (WHO) reported that NCDs account for 74% of global deaths. An imbalance between free radicals and antioxidants contributes to the progression of these diseases, highlighting the need for research on plant-derived antioxidants. Secondary metabolites, particularly phenolic and flavonoid compounds, are abundant in Chrysanthemum indicum and are known for their potential antioxidant properties. This study aims to identify the secondary metabolites and evaluate the antioxidant activity of yellow chrysanthemum (Chrysanthemum indicum) leaves using two methods: Ferric Reducing Antioxidant Power (FRAP) and 2,2-diphenyl-1-picrylhydrazyl (DPPH). The extraction process was performed using the reflux method with 96% ethanol as the solvent. Antioxidant activity was assessed using the DPPH and FRAP methods, with absorbance measurements conducted via UV-Vis spectrophotometry. Phytochemical screening revealed the presence of phenols, flavonoids, tannins, steroids/triterpenoids, and alkaloids in the ethanol extract of yellow chrysanthemum leaves. The antioxidant activity assay using the DPPH method indicated a value of 64.34 ppm, signifying strong antioxidant activity. In contrast, the FRAP method showed weak antioxidant activity, with an IC50 value of 187.13 ppm.
Investigating the Anti-Inflammatory Potential of Ethanol Extracts from Purple Chrysanthemum Flowers Gilbert Samuel Sumakul; Fatimawali Fatimawali; Widdhi Bodhi; Fona Hermina Dwiana Budiarso; Billy Johnson Kepel; Aaltje Manampiring
Grimsa Journal of Science Engineering and Technology Vol. 3 No. 2 (2025): October 2025
Publisher : Graha Primera Saintifika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61975/gjset.v3i2.69

Abstract

Indonesia has high biodiversity, with around 9,600 species of flora possessing medicinal properties. One such plant is the purple chrysanthemum (Chrysanthemum morifolium), which is rich in bioactive compounds with anti-inflammatory potential. The purple chrysanthemum is used in traditional medicine to treat various diseases and has demonstrated significant anti-inflammatory activity in vitro. Given the high prevalence of inflammatory diseases in Indonesia and the side effects associated with conventional drugs, this plant is considered a promising alternative therapy that may be safer and more effective. The aim of this study was to identify the phytochemical compounds and evaluate the anti-inflammatory activity of an ethanol extract from purple chrysanthemum flowers (Chrysanthemum morifolium) in vitro. The extract was prepared using 96% ethanol, and its anti-inflammatory activity was assessed using the red blood cell membrane stabilization method. Blood samples were collected from Wistar rats. The inhibitory concentration (IC50) values of the extract and Diclofenac Sodium were 203.08 ppm and 224.04 ppm, respectively. These findings indicate that the ethanol extract of purple chrysanthemums exhibits anti-inflammatory activity
Co-Authors Aaltje Ellen Manampiring Aaltje Manampiring Billy Johnson Kepel Fatimawali Fatimawali Fona Dwiana Hermina Budiarso Fona Hermina Dwiana Budiarso Gabriella Therezia Ley Ley Gilbert Samuel Sumakul