Article Per Year (5 Year)
p-Index From 2021 - 2026
0.23
P-Index
This Author published in this journals
All Journal Jurnal Kesehatan (JK)
Alya Salsabillah Manangin
Prodi Sarjana Farmasi Fakultas Kedokteran Dan Ilmu Kesehatan, Universitas Muhammadiyah Makassar, Indonesia
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
KONTRIBUSI TIKUS PUTIH DALAM KEMAJUAN FARMAKOLOGI Alya Salsabillah Manangin
Jurnal Kesehatan Vol. 3 No. 5 (2025): MEI
Publisher : CV. Adiba Aisha Amira

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

White rats (Rattus norvegicus) are the most commonly used laboratory animals in pharmacological and toxicological research due to their physiological similarities to humans, ease of handling, and cost efficiency. This article discusses proper handling techniques for white rats as research subjects to ensure the validity of results and animal welfare. Crucial aspects reviewed include ethical standards for laboratory animal use, optimal maintenance techniques covering cage conditions, nutrition, light cycles, and temperature control, as well as handling methods that minimize stress. The discussion includes acclimatization procedures, safe restraint techniques, methods of drug administration through various routes, blood and tissue sampling techniques, and health monitoring parameters. Humane euthanasia methods in accordance with ethical protocols are also outlined. The application of the 3R principles (Replacement, Reduction, Refinement) in research design is discussed as an ethical framework that must be implemented. Understanding and applying proper handling techniques for white rats not only improves the quality and reliability of pharmacological and toxicological research data but also ensures animal welfare aspects that are the moral responsibility of researchers.
Co-Authors