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All Journal Jurnal Kesehatan (JK) ZAHRA (JOURNAL OF HEALTH AND MEDICAL RESEARCH)
Aulia Risqi Fatmariza
D3 Teknologi Laboratorium Medis, Fakultas Teknologi dan Manajemen Kesehatan, Institut Ilmu Kesehatan Bhakti Wiyata, Kediri, Indonesia
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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PERBEDAAN KADAR INTERLEUKIN-6 PADA PENDERITA DIABETES MELITUS TIPE 2 TERKONTROL DAN TIDAK Angga Eka Kurniawan; Aulia Risqi Fatmariza
Jurnal Kesehatan Vol. 2 No. 5 (2024): Jurnal Kesehatan (JK)
Publisher : CV. Adiba Aisha Amira

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Background: Type 2 Diabetes Mellitus (T2DM) is a chronic, non-communicable disease that progresses slowly due to multifactorial etiology. Chronic low-grade inflammation plays an important role in the pathogenesis of T2DM, thereby linking diabetes to a number of common conditions thought to originate from inflammatory mechanisms. IL-6 is considered an independent risk factor and acts as a marker of insulin resistance and development of T2DM. High extracellular glucose levels will trigger an increase in oxidative stress which will increase ROS production and lead to inflammation. Objective: To prove that there are diflerences in IL-6 levels in controlled and uncontrolled T2DM suflerers. Research method: The type of research is analytical observational, with a cross sectional research design and non-probability sampling technique with a purposive sampling method in the laboratory of RSU Muhammadiyah Roemani Semarang in November-December 2022. Results: The results of the study showed that the mean value of IL-6 levels in T2DM controlled at 4.37 pg/ml and uncontrolled T2DM at 76.07 pg/ml. Based on Mann-Whitney U statistical analysis, it was found that the p value was <0.05, thus proving that there was a significant diflerence in IL-6 levels in controlled and non-controlled T2DM suflerers. Conclusion: There is a diflerence in IL-6 levels in controlled and uncontrolled T2DM suflerers, where IL-6 levels in uncontrolled T2DM suflerers are higher than in controlled T2DM suflerers.
COMPARISON OF HOMOGENEITY BETWEEN LYOPHILISED CONTROL MATERIAL AND IN-HOUSE CONTROL MATERIAL FOR GLUCOSE EXAMINATION Aulia Risqi Fatmariza; Angga Eka Kurnia, Danny Meganingdyah Primartati
ZAHRA: JOURNAL OF HEALTH AND MEDICAL RESEARCH Vol. 4 No. 2 (2025): ZAHRA (JOURNAL OF HEALTH AND MEDICAL RESEARCH)
Publisher : CV. ADIBA AISHA AMIRA

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Background: Internal Quality Assurance (IQA) is a continuous monitoring activity by the laboratory to reduce or prevent errors in examination results using control materials. Homogeneity of the control material is very important because homogeneity shows that the control material is the same. Objective: To find out whether there is a difference in homogeneity between the lyophilized control material and the in-house control material for glucose examination. Research method: The type of research used was a quasi experiment with a simple random sampling technique at the SMC Clinical Laboratory, Telogorejo Hospital, Semarang. Data analysis uses the homogeneity calculation formula. Results: Based on the results of homogeneity calculations, it is known that the Fcount for the lyophilized control material is 0.9538 while the in-house control material is 2.1883, where both are <Ftable (3.02) which means homogeneous. Conclusion: There is no difference in homogeneity between lyophilized control material and in-house control material for glucose examination.
Co-Authors Angga Eka Kurnia, Danny Meganingdyah Primartati Angga Eka Kurniawan