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All Journal Sanitas: Journal of Health, Medical, and Psychological Studie
Ryan Raditya
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Health Professions Medicine & Pharmacology

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Pengaruh Pemberian Pestisida Diazinon Terhadap Peningkatan Kadar SGPT (Serum Glutamic Pyruvic Transaminase) Mencit Jantan Ryan Raditya
Journal of Health, Medical, and Psychological Studies Vol 2 No 1 (2026): : August: Sanitas: Journal of Health, Medical, and Psychological Studies
Publisher : CV SCRIPTA INTELEKTUAL MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.65310/5jtdxx14

Abstract

This study aimed to evaluate the effect of diazinon pesticide exposure on serum glutamic pyruvic transaminase (SGPT) levels in male mice as a biomarker of liver injury. A true experimental design with a posttest-only control group approach was implemented using 25 male mice (Mus musculus) randomly assigned into one control group and four treatment groups with graded diazinon doses. The exposure was administered orally for 10 consecutive days under controlled laboratory conditions. Blood samples were collected to measure SGPT levels using a kinetic spectrophotometric method. Statistical analysis was conducted using one-way ANOVA followed by post hoc testing to determine intergroup differences. The findings demonstrated a significant elevation of SGPT levels in all treatment groups compared to the control (p < 0.05), indicating hepatocellular damage. Further analysis revealed significant differences between treatment groups, suggesting a dose-related toxic effect. These results confirm that diazinon exposure induces liver dysfunction and enzymatic alterations, emphasizing its hepatotoxic potential.  
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