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Relationship between Dietary Oxalate Intake and Urinary Oxalate Excretion in Patients with Nephrolithiasis : A Systematic Review Yuni Agnes Lubis; Dini Miori; Heri Setiawan
The International Journal of Medical Science and Health Research Vol. 43 No. 2 (2026): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/9j3aaq57

Abstract

Introduction: Nephrolithiasis, particularly calcium oxalate (CaOx) stones, is strongly influenced by urinary oxalate excretion. Dietary oxalate intake is a modifiable risk factor, but its quantitative relationship with urinary oxalate and the comparative effectiveness of dietary strategies remain debated. This systematic review evaluates the positive significant relationship between dietary oxalate intake and urinary oxalate excretion in nephrolithiasis patients. Methods: A systematic search was performed for human studies assessing both dietary oxalate intake and urinary oxalate excretion in nephrolithiasis patients. Data on study design, dietary assessment, urinary oxalate measurement, intervention effects, and confounding factors were extracted. Results: The foundational quantitative estimate shows that for every 100 mg of dietary oxalate consumed, urinary oxalate increases by approximately 2.7 mg (1). Dietary oxalate accounts for 25-53% of total urinary oxalate (2). Low-oxalate dietary interventions significantly reduce urinary oxalate by 20-35% in idiopathic hyperoxaluria (3-5). In the prospective randomized trial by Gupta et al., low-oxalate diet reduced urinary oxalate by 31.1% (P=0.007) (3). Aziz et al. reported a 48.9% reduction (23). Normal-calcium, low-protein, low-salt diet reduced oxaluria by 78 µmol/day (95% CI 26.48-129.52) and stone recurrence (RR 0.77) (30). Dietary counseling significantly lowered urinary oxalate from 46.28 to 32.56 mg/day (P<0.0001) (6). Mediterranean diet adherence was associated with 13-41% lower stone risk (pooled HR 0.72, 95% CI 0.59-0.87) despite higher urinary oxalate (16). Calcium intake with meals significantly reduces urinary oxalate (7,25), while ascorbic acid supplementation increases urinary oxalate by 20-33% (12,21). Enteric hyperoxaluria shows attenuated response to dietary restriction alone (8,9). Discussion: A consistent positive association exists between dietary oxalate and urinary oxalate, with significant reductions from low-oxalate diets. However, multi-component dietary patterns (DASH, Mediterranean) may provide superior overall lithogenic risk reduction by improving citrate, magnesium, and urine volume. Conclusion: Dietary oxalate restriction significantly reduces urinary oxalate in idiopathic hyperoxaluria. Meal-concurrent calcium intake and comprehensive dietary patterns are more effective than oxalate restriction alone. Enteric hyperoxaluria requires additional therapies.
Identification of Risk Factors for Urinary Tract Stones in Rural Populations : A Systematic Review Vachroul Rauzi; Dinda Pebriani Simbolon; Heri Setiawan; Yuni Agnes Lubis; Nasribar
The International Journal of Medical Science and Health Research Vol. 45 No. 2 (2026): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/kaw8nv91

Abstract

Introduction: Urinary tract stones (UTS) are a growing global health concern, yet risk factors in rural populations remain poorly synthesized due to distinct environmental, occupational, and dietary exposures. This systematic review identifies significant risk factors for UTS specifically in rural settings. Methods: A systematic review of 80 studies (RCT, etc) from global databases was conducted. Studies were included if they reported on rural populations or provided separate rural subgroup analyses for UTS risk factors. Results: Key positive risk factors identified include: male sex (male-to-female ratio up to 10.5:1 in endemic pediatric bladder stone disease) (2,3); family history (OR=16.98, 95%CI:3.02-95.25) (9); low fluid intake (OR=2.64, 95%CI:2.00-3.48) (6); red meat consumption (OR=32.28, 95%CI:9.7-143.2) (9); high sodium (OR=1.88) (6); obesity (OR=2.36) (6); diabetes (OR=1.68) (4); hypertension (OR=2.04) (4); ambient temperature (10% increased risk per 5°C) (7); occupational heat exposure (ninefold risk) (8); cadmium exposure (RR=1.07 per 1.0 µg/L urinary cadmium) (12); and phthalate exposure (13). Hypocitraturia (91.3% prevalence) and hypercalciuria (68.5%) were the most common metabolic abnormalities in rural stone formers (5). Distinct rural stone types include ammonium urate (endemic bladder stones in South Asian children) (2) and struvite (infection-related). Discussion: Rural UTS risk operates via three distinct pathways: 1) poverty-driven endemic disease (protein deficiency, dehydration, infection) producing ammonium urate stones; 2) adult calcium oxalate disease driven by nutritional transition (metabolic syndrome, high animal protein, low fluid intake); and 3) environmental toxicant-related disease (cadmium, phthalates) from agricultural/industrial exposures. Healthcare access barriers delay diagnosis, increasing stone burden at presentation (14). Conclusion: Rural populations face unique, amplified UTS risk factors requiring context-specific interventions: ensuring potable water access at worksites, dietary protein supplementation in endemic bladder stone regions, metabolic syndrome management, and environmental remediation of heavy metals.
Diagnosis and Management of Eye Trauma in Primary Care Settings : A Systematic Review Dinda Pebriani Simbolon; Vachroul Rauzi; Yuni Agnes Lubis
The International Journal of Medical Science and Health Research Vol. 45 No. 2 (2026): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/zkdmv147

Abstract

Introduction: Eye trauma is a common presentation in primary care and emergency settings, yet guidance tailored to non-ophthalmologists remains fragmented. This review synthesises evidence on diagnosis, management, and triage of eye trauma to support primary care practitioners. Methods: A systematic review of 80 studies (2006–2026) including RCTs, etc. Populations included all ages with acute eye trauma. Outcomes focused on diagnostic accuracy, treatment efficacy, referral criteria, and visual outcomes. Results: Males predominate (62.8–99.3%) across all injury types. Corneal abrasions are the most common presentation (up to 80%). Topical NSAIDs reduce rescue analgesia (RR 0.46, p<0.01) but do not accelerate healing (1,2,3). Eye patching provides no benefit over no patching (4). Short-term topical tetracaine (24 hours) significantly reduces pain scores (NRS 1 vs 8, Δ7) without increased complications (5). Systemic tranexamic acid reduces secondary haemorrhage in traumatic hyphema (RR 0.31) (6). Point-of-care ultrasonography by non-ophthalmologists achieves 94% sensitivity and specificity for retinal detachment (7,8). Four independent predictors mandate urgent referral: visual acuity change, abnormal pupillary response, retrobulbar haemorrhage, and inability to open the eye (9,10,11). The Ocular Trauma Score correlates strongly with final vision (r=0.93) (12). Discussion: Primary care physicians demonstrate good inter-rater reliability versus ophthalmology when examinations are performed (sensitivity 60.6%, specificity 84.2%) (13). A substantial proportion of eye-related ED visits are non-urgent (39.5–53.5%) (14,15), indicating many cases are suitable for primary care. Cyanoacrylate tissue adhesive for periorbital lacerations in children achieves equivalent healing to sutures with shorter procedure time (184 vs 692 seconds) (16). Protective eyewear reduces firework injuries (OR 0.65) (17), and restrictive legislation reduces eye trauma by 87% (18). Conclusion: Most eye trauma can be managed safely in primary care using structured clinical assessment. Key positive findings include NSAIDs for pain, short-term topical anaesthetics for corneal abrasions, tranexamic acid for hyphema, and POCUS for posterior chamber evaluation. Four clinical predictors reliably identify patients needing urgent referral.