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All Journal SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL
Octaviani, Egy
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Health Professions Medicine & Pharmacology Public Health Social Sciences

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EVALUASI FUNGSI GINJAL BERDASARKAN FARMAKOKINETIK EKSKRESI PADA PASIEN HIPERTENSI DI INSTALASI RAWAT INAP RSUD CILINCING JAKARTA UTARA Octaviani, Egy; Amirulah, Fajar; Sari, Dini Permata; Astiani, Rangki
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 11, No 1 (2026)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v11i1.8932

Abstract

Hypertension is a major risk factor for impaired renal function, which may progress to chronic kidney disease (CKD). This study aimed to evaluate renal function based on excretory pharmacokinetic parameters (urea, creatinine, and creatinine clearance) in hypertensive inpatients, and to assess the impact of patient characteristics and types of antihypertensive drugs on renal function decline. This observational analytic study with a cross-sectional design utilized secondary data from 100 medical records of hypertensive inpatients at RSUD Cilincing, North Jakarta, collected during March–April 2025. Most patients were classified in CKD stages 2–3a. The most frequently prescribed therapies were calcium channel blockers (CCBs) and angiotensin receptor blockers (ARBs). Chi-Square analysis revealed significant associations between renal function and gender, age, and CCB use (p < 0.05), while diuretic use was not significantly associated (p = 0.134). These findings highlight the importance of appropriate antihypertensive drug selection and regular renal monitoring to prevent CKD progression in hypertensive patients.
Co-Authors Astiani, Rangki Fajar Amirulah Sari, Dini Permata