Cytotoxic Activity of Citral from Cymbopogon nardus as Anticancer of MCM-B2 Cell

Hasim Hasim (Department of Biochemistry, Faculty of Mathematics and Natural Sciences, IPB University)
Surya Pangidoan Nasution (Department of Biochemistry, Faculty of Mathematics and Natural Sciences, IPB University)
Silvi Octavia Kurniawati (Department of Biochemistry, Faculty of Mathematics and Natural Sciences, IPB University)
Indah Rachmawati (Department of Biochemistry, Faculty of Mathematics and Natural Sciences, IPB University)

Current Biochemistry
Vol. 7 No. 1 (2020)

Cancer is a deadly disease caused by cell abnormalities characterized by uncontrolled cell growth. One type of cancer that is the second leading cause of death is breast cancer. Lemongrass (Cymbopogon nardus) is a plant containing citral and geraniol which has the potential as an anticancer. This research was aimed to analyze the potential of essential oils from citronella as antiproliferation of MCM-B2 breast cancer cells. The results of this research showed that lemongrass essential oil was able to significantly reduce the growth of MCM-B2 cancer cells (p<0.05). The concentration of 3 ppm showed an significant difference in doxorubicin, and the concentration of 24 ppm had the highest inhibitory activity with an IC50 value of 5.38 ppm. Keywords: Antiproliferation, breast cancer, MCM-B2, essential oils, fragrant lemongrass