Chimica et Natura Acta
Vol 4, No 3 (2016)

RESOLUTION OF A RACEMIC ISOLEUCINE MIXTURE BY USING METHYL L-MANDELATE

Rani Maharani (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran)
Ace Tatang Hidayat (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran)
Dadan Sumiarsa (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran)
Achmad Zainuddin (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran)
Ika Wiani Hidayat (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran)

Article Info

Publish Date
12 Dec 2016

Abstract

A methyl ester of L-mandelic acid was found to be an effective resolving agent for resolution of commercial DL-isoleucine. The resolution was based on Steglich esterification between methyl L-mandelate and Boc-DL-isoleucine. The two resolved isomers were easily separated by using a conventional flash-column chromatography, giving quantitatively good yields. Unfortunately, the methyl L-mandelate was found to be ineffective to resolve four stereoisomers of Fmoc- isoleucine.

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Journal Info
Chimica et Natura Acta
Website

Abbrev

jcena

Publisher

Universitas Padjadjaran

Subject

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Environmental Science Materials Science & Nanotechnology

Description

Chimica et Natura Acta diterbitkan oleh Departemen Kimia, FMIPA, Universitas Padjadjaran tiga kali setiap tahun pada bulan April, Agustus dan Desember. Artikel yang dimuat mencakup Kimia Analisis dan Pemisahan, Kimia Material, Kimia Energi dan Lingkungan, Kimia Organik Bahan Alam dan Sintesis, ...