Jambura Journal of Chemistry
Vol 1, No 2 (2019): August

QSAR Study of Indolylisoxazoline Analogues for Their Antiprostat Activity

Jafar La Kilo (Program Studi Kimia, FMIPA Universitas Negeri Gorontalo)
Akram La Kilo (Program Studi Kimia, FMIPA Universitas Negeri Gorontalo)

Article Info

Publish Date
30 Sep 2019

Abstract

ABSTRACT Quantitative Structure-Activity relationship study of 13 Indolylisoxazoline analogues as antiprostat agent using multiple linear regression (MLR) has been done. Geometri optimization of Indolylisoxazoline analogues using molecular mechanics (MM+) method. The best QSAR model from regression analysis is log IC50 Pred = 30,877 - 71,847 x qC10 + 165,070 x qC11 + 70,106 x qC13 with most influents descriptor to antiprostat activity are qC10, qC11 dan qC13.

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Journal Info
Jambura Journal of Chemistry
Website

Abbrev

jjc

Publisher

Universitas Negeri Gorontalo

Subject

Chemistry

Description

Jambura Journal of Chemistry is peer-reviewed and open access journal published by Chemistry Depertment, Faculty Mathematic and Natural Science. Jam.J.Chem that publishes original research articles, review articles, as well as short communication in all areas of chemistry including applied ...