Journal of Food and Pharmaceutical Science
Vol 2, No 3 (2014): J. Food Pharm. Sci (Sept-December)

Simultaneous Determination Of Metamizole, Thiamin And Pyridoxin In Multicomponent Tablet by RP-HPLC

Chotimah, Chusnul (Unknown)

Article Info

Publish Date
16 Jun 2014

Abstract

The aim of the study was to develop and validate high performance liquid chromatography (HPLC) assay for the simultaneous determination of Metamizole, Thiamine and Pyridoxin in multicomponent tablet dosage form. The experimental procedure involved reversed-phase-HPLC with a Atlantis T3 C18 column (5 μm particle size, 4.6 ID x 150 mm), PIC solution-metanol-acetic acid volumetric  solution (700: 300 : 4, v/v/v) mobile phase, UV detection at 275 nm. The flow rate of the mobile phase was 1.2 mL/min. The method was validated with respect to specificity,  precision, accuracy  and linearity. Due to its simplicity and accuracy, the assay method is suitable for routine analysis of multiomponen tablet formulation.  Key words : metamizole, thiamine, pyridoxin, HPLC

Copyrights © 2014




Citation Download
RIS
EndNote, Reference Manager, ProCite
BibTex
Latex, Jabref
Full PDF
359.516 KB
Original Source
Download Original
Google Scholar
Check in Google Scholar
Journal Info
Journal of Food and Pharmaceutical Science
Website

Abbrev

jfps

Publisher

Universitas Gadjah Mada

Subject

Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology

Description

FOCUS AND SCOPE Journal of Food and Pharmaceutical Sciences offers scientists, researchers, and other professionals to share knowledge of scientific advancements. The journal will publish original research articles, review articles, short communication, and letter to editor. The area of focus should ...